Literature DB >> 9376333

Memory and intellectual deficits do not decline with age in schizophrenia.

D Mockler1, J Riordan, T Sharma.   

Abstract

Cognitive deficits in schizophrenia are reported to be more consistent with a static encephalopathy than a dementing disorder. This study investigates memory and intellectual decline in 62 chronic schizophrenic subjects using the Wechsler Adult Intelligence Scale-Revised (WAIS-R), the Rivermead Behavioural Memory Test and the National Adult Reading Test (NART) in a cross-sectional study using five age cohorts (18-29, 30-39, 40-49, 50-59 and 60-69 years of age) and then by two cohorts (young: 18-39; older: 40-69). A second method of investigating intellectual decline was implemented by estimating the discrepancy score between WAIS-R (current IQ) and NART (premorbid IQ) for each subject. No significant differences were found in WAIS-R Full Scale. Verbal and Performance IQ and memory functioning across the five age cohorts (and when using two age groups). A significant difference in test scores was found using the Picture Completion and Digit Symbol subtests of the WAIS-R. The differences were not related to age or duration of illness. No significant difference in scores were evident in the remaining WAIS-R subtests. These results support previous findings that schizophrenia is more consistent with a static encephalopathy than a dementing disorder and that intellectual and memory function does not markedly decline with age.

Entities:  

Mesh:

Year:  1997        PMID: 9376333     DOI: 10.1016/S0920-9964(97)00031-5

Source DB:  PubMed          Journal:  Schizophr Res        ISSN: 0920-9964            Impact factor:   4.939


  6 in total

1.  Cognitive impairment from early to middle adulthood in patients with affective and nonaffective psychotic disorders.

Authors:  Josephine Mollon; Samuel R Mathias; Emma E M Knowles; Amanda Rodrigue; Marinka M G Koenis; Godfrey D Pearlson; Abraham Reichenberg; Jennifer Barrett; Dominique Denbow; Katrina Aberizk; Molly Zatony; Russell A Poldrack; John Blangero; David C Glahn
Journal:  Psychol Med       Date:  2019-01-04       Impact factor: 7.723

Review 2.  Verbal declarative memory dysfunction in schizophrenia: from clinical assessment to genetics and brain mechanisms.

Authors:  Michael A Cirillo; Larry J Seidman
Journal:  Neuropsychol Rev       Date:  2003-06       Impact factor: 7.444

Review 3.  Hospitalization and psychosis: influences on the course of cognition and everyday functioning in people with schizophrenia.

Authors:  Philip D Harvey; David A Loewenstein; Sara J Czaja
Journal:  Neurobiol Dis       Date:  2012-10-31       Impact factor: 5.996

4.  Age-associated differences in cognitive performance in older community dwelling schizophrenia patients: differential sensitivity of clinical neuropsychological and experimental information processing tests.

Authors:  Christopher R Bowie; Abraham Reichenberg; Margaret M McClure; Winnie L Leung; Philip D Harvey
Journal:  Schizophr Res       Date:  2007-11-28       Impact factor: 4.939

5.  Neurological abnormalities in recent-onset schizophrenia and asperger-syndrome.

Authors:  Dusan Hirjak; Robert Christian Wolf; Sabine C Koch; Laura Mehl; Janna K Kelbel; Katharina Maria Kubera; Tanja Traeger; Thomas Fuchs; Philipp Arthur Thomann
Journal:  Front Psychiatry       Date:  2014-08-06       Impact factor: 4.157

6.  The computational anatomy of psychosis.

Authors:  Rick A Adams; Klaas Enno Stephan; Harriet R Brown; Christopher D Frith; Karl J Friston
Journal:  Front Psychiatry       Date:  2013-05-30       Impact factor: 4.157

  6 in total

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