Literature DB >> 9373246

Hydroxyurea can be used to increase mouse c-kit+Thy-1. 1(lo)Lin-/loSca-1(+) hematopoietic cell number and frequency in cell cycle in vivo.

N Uchida1, A M Friera, D He, M J Reitsma, A S Tsukamoto, I L Weissman.   

Abstract

The DNA synthesis inhibitor hydroxyurea (HU) was administered to determine whether it induces changes in the cell-cycle status of primitive hematopoietic stem cells (HSCs)/progenitors. Administration of HU to mice leads to bone marrow accumulation of c-kit+Thy-1.1(lo)Lin-/loSca-1(+) (KTLS) cells in S/G2/M phases of the cell cycle. HU is a relatively nontoxic, reversible cell-cycle agent that can lead to approximately a threefold expansion of KTLS cells in vivo and approximately an eightfold increase in the number of KTLS cells in S/G2/M. HSCs in HU-treated mice have undiminished multilineage long-term and short-term clonal reconstitution activity.

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Year:  1997        PMID： 9373246

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  10 in total

1.  In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells.

Authors:  S H Cheshier; S J Morrison; X Liao; I L Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-16       Impact factor: 11.205

2.  c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation.

Authors:  Anne Wilson; Mark J Murphy; Thordur Oskarsson; Konstantinos Kaloulis; Michael D Bettess; Gabriela M Oser; Anne-Catherine Pasche; Christian Knabenhans; H Robson Macdonald; Andreas Trumpp
Journal:  Genes Dev       Date:  2004-11-15       Impact factor: 11.361

3.  Tolerance and immunity after sequential lung and bone marrow transplantation from an unrelated cadaveric donor.

Authors:  Paul Szabolcs; Rebecca H Buckley; Robert Duane Davis; Jerelyn Moffet; Judith Voynow; Jeyaraj Antony; Xiaohua Chen; Gregory D Sempowski; David W Zaas
Journal:  J Allergy Clin Immunol       Date:  2014-09-26       Impact factor: 10.793

4.  Bid protects the mouse hematopoietic system following hydroxyurea-induced replicative stress.

Authors:  Y Liu; A Aiello; S S Zinkel
Journal:  Cell Death Differ       Date:  2012-04-20       Impact factor: 15.828

5.  Cytosine arabinoside reduces the numbers of granulocyte macrophage colony forming cells (GM-CFC) and high proliferative potential colony forming cells (HPP-CFC) in vivo in mice.

Authors:  Stanley Teleka; Alexander Chijuwa; Edward Senga; John E Chisi
Journal:  Malawi Med J       Date:  2011-12       Impact factor: 0.875

6.  A novel reduced-intensity conditioning regimen for unrelated umbilical cord blood transplantation in children with nonmalignant diseases.

Authors:  Suhag H Parikh; Adam Mendizabal; Cara L Benjamin; Krishna V Komanduri; Jeyaraj Antony; Aleksandra Petrovic; Gregory Hale; Timothy A Driscoll; Paul L Martin; Kristin M Page; Ketti Flickinger; Jerelyn Moffet; Donna Niedzwiecki; Joanne Kurtzberg; Paul Szabolcs
Journal:  Biol Blood Marrow Transplant       Date:  2013-12-01       Impact factor: 5.742

7.  Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells.

Authors:  Xiuli Wang; Shundi Ge; George McNamara; Qian-Lin Hao; Gay M Crooks; Jan A Nolta
Journal:  Blood       Date:  2003-01-30       Impact factor: 22.113

8.  Reduced-intensity single-unit unrelated cord blood transplant with optional immune boost for nonmalignant disorders.

Authors:  Mark T Vander Lugt; Xiaohua Chen; Maria L Escolar; Beth A Carella; Jessie L Barnum; Randy M Windreich; Memphis J Hill; Michelle Poe; Rebecca A Marsh; Heather Stanczak; Elizabeth O Stenger; Paul Szabolcs
Journal:  Blood Adv       Date:  2020-07-14

9.  Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates.

Authors:  Emmanuelle Passegué; Amy J Wagers; Sylvie Giuriato; Wade C Anderson; Irving L Weissman
Journal:  J Exp Med       Date:  2005-12-05       Impact factor: 14.307

10.  A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer.

Authors:  Alfredo Cruz-Ramírez; Sara Díaz-Triviño; Guy Wachsman; Yujuan Du; Mario Arteága-Vázquez; Hongtao Zhang; Rene Benjamins; Ikram Blilou; Anne B Neef; Vicki Chandler; Ben Scheres
Journal:  PLoS Biol       Date:  2013-11-26       Impact factor: 8.029
  10 in total

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