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Literature DB >> 9373178

TNF-alpha induces apoptosis in rat fetal brown adipocytes in primary culture.

A Porras¹, A M Alvarez, A Valladares, M Benito.

Abstract

The effect of TNF-alpha on cell death in rat fetal brown adipocytes maintained in primary culture was determined. TNF-alpha inhibited proliferation and induced apoptosis in these cells. Most of the cells undergoing apoptosis after TNF-alpha treatment did not express PCNA, suggesting an induction of apoptosis by TNF-alpha in non-proliferative cells. IGF-I but not EGF prevented TNF-alpha-induced apoptosis.

Entities: Gene Species

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Year: 1997 PMID： 9373178 DOI： 10.1016/s0014-5793(97)01204-0

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

14 in total

1. Silencing SOCS3 could inhibit TNF-α induced apoptosis in 3T3-L1 and mouse preadipocytes.

Authors: Xia Zhao; Renli Qi; Chao Sun; Yunfei Xie
Journal: Mol Biol Rep Date: 2012-06-20 Impact factor: 2.316

2. Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity.

Authors: E Nisoli; L Briscini; A Giordano; C Tonello; S M Wiesbrock; K T Uysal; S Cinti; M O Carruba; G S Hotamisligil
Journal: Proc Natl Acad Sci U S A Date: 2000-07-05 Impact factor: 11.205

3. Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes.

Authors: Angela M Valverde; Cecilia Mur; Michael Brownlee; Manuel Benito
Journal: Mol Biol Cell Date: 2004-09-08 Impact factor: 4.138

Review 4. TNF-alpha and adipocyte biology.

Authors: William P Cawthorn; Jaswinder K Sethi
Journal: FEBS Lett Date: 2007-11-26 Impact factor: 4.124

Review 9. Brown adipose tissue: endocrine determinants of function and therapeutic manipulation as a novel treatment strategy for obesity.

Authors: Narendra L Reddy; Bee K Tan; Thomas M Barber; Harpal S Randeva
Journal: BMC Obes Date: 2014-08-22

10. Brown adipose tissue plays a central role in systemic inflammation-induced sleep responses.

Authors: Éva Szentirmai; Levente Kapás
Journal: PLoS One Date: 2018-05-10 Impact factor: 3.240

TNF-alpha induces apoptosis in rat fetal brown adipocytes in primary culture.

1. Silencing SOCS3 could inhibit TNF-α induced apoptosis in 3T3-L1 and mouse preadipocytes.

2. Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity.

3. Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes.

Review 4. TNF-alpha and adipocyte biology.

5. Endothelial cell apoptosis in brown adipose tissue of rats induced by hyperinsulinaemia: the possible role of TNF-α.

Review 6. Endocrine disrupting chemicals: Friend or foe to brown and beige adipose tissue?

7. Anti-obesity effects of granulocyte-colony stimulating factor in Otsuka-Long-Evans-Tokushima fatty rats.

Review 8. Influencing Factors of Thermogenic Adipose Tissue Activity.

Review 9. Brown adipose tissue: endocrine determinants of function and therapeutic manipulation as a novel treatment strategy for obesity.

10. Brown adipose tissue plays a central role in systemic inflammation-induced sleep responses.