Literature DB >> 9373153

Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene.

K L Thorpe1, P Gorman, C Thomas, D Sheer, J Trowsdale, S Beck.   

Abstract

We have mapped the human ORFX gene to chromosome 9q34 and determined its complete gene structure. Comparison with RING3, the human MHC-linked homologue on 6p21.3, shows the two gene structures to be highly conserved but with an approximate threefold expansion in the ORFX introns. RING3 and ORFX are found to be ubiquitously expressed in human adult and foetal tissues. Evidence suggests that the two genes may have arisen from an ancient duplication in a common ancestral chromosome.

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Year:  1997        PMID： 9373153     DOI： 10.1016/s0378-1119(97)00415-0

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  12 in total

1.  A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition.

Authors:  A Dey; J Ellenberg; A Farina; A E Coleman; T Maruyama; S Sciortino; J Lippincott-Schwartz; K Ozato
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

Review 2.  Bromodomain coactivators in cancer, obesity, type 2 diabetes, and inflammation.

Authors:  Gerald V Denis
Journal:  Discov Med       Date:  2010-12       Impact factor: 2.970

3.  Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3.

Authors:  Roland Gamsjaeger; Sarah R Webb; Janine M Lamonica; Andrew Billin; Gerd A Blobel; Joel P Mackay
Journal:  Mol Cell Biol       Date:  2011-05-09       Impact factor: 4.272

4.  Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.

Authors:  Denis Houzelstein; Simon L Bullock; Denise E Lynch; Elena F Grigorieva; Valerie A Wilson; Rosa S P Beddington
Journal:  Mol Cell Biol       Date:  2002-06       Impact factor: 4.272

5.  RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F.

Authors:  G V Denis; C Vaziri; N Guo; D V Faller
Journal:  Cell Growth Differ       Date:  2000-08

Review 6.  An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis.

Authors:  Gerald V Denis; Barbara S Nikolajczyk; Gavin R Schnitzler
Journal:  FEBS Lett       Date:  2010-05-21       Impact factor: 4.124

7.  BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy.

Authors:  Deb K Pal; Oleg V Evgrafov; Paula Tabares; Fengli Zhang; Martina Durner; David A Greenberg
Journal:  Am J Hum Genet       Date:  2003-06-25       Impact factor: 11.025

8.  BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses.

Authors:  Anna C Belkina; Barbara S Nikolajczyk; Gerald V Denis
Journal:  J Immunol       Date:  2013-02-18       Impact factor: 5.422

Review 9.  The role of the double bromodomain-containing BET genes during mammalian spermatogenesis.

Authors:  Binyamin D Berkovits; Debra J Wolgemuth
Journal:  Curr Top Dev Biol       Date:  2013       Impact factor: 4.897

10.  Structures of the dual bromodomains of the P-TEFb-activating protein Brd4 at atomic resolution.

Authors:  Friederike Vollmuth; Wulf Blankenfeldt; Matthias Geyer
Journal:  J Biol Chem       Date:  2009-10-13       Impact factor: 5.157
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