| Literature DB >> 9372601 |
A Pedretti1, A M Villa, L Villa, G Vistoli.
Abstract
The automated stochastic docking procedure BioDock has been applied to a series of inhibitors of PGH synthase, the key enzyme in the synthesis of eicosanoids from arachidonic acid. Some PGHS-2 selective inhibitors have been docked to the structure of the ovine PGHS-1 enzyme, as recently obtained by means of X-ray crystallographic analysis, in order to highlight possible structural bases for selectivity.Entities:
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Year: 1997 PMID： 9372601
Source DB: PubMed Journal: Farmaco ISSN： 0014-827X