| Literature DB >> 9371841 |
M P Smidt1, H S van Schaick, C Lanctôt, J J Tremblay, J J Cox, A A van der Kleij, G Wolterink, J Drouin, J P Burbach.
Abstract
The mesencephalic dopaminergic (mesDA) system regulates behavior and movement control and has been implicated in psychiatric and affective disorders. We have identified a bicoid-related homeobox gene, Ptx3, a member of the Ptx-subfamily, that is uniquely expressed in these neurons. Its expression starting at E11.5 in the developing mouse midbrain correlates with the appearance of mesDA neurons. The number of Ptx3-expressing neurons is reduced in Parkinson patients, and these neurons are absent from 6-hydroxydopamine-lesioned rats, an animal model for this disease. Thus, Ptx3 is a unique transcription factor marking the mesDA neurons at the exclusion of other dopaminergic neurons, and it may be involved in developmental determination of this neuronal lineage.Entities:
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Year: 1997 PMID： 9371841 PMCID： PMC24304 DOI： 10.1073/pnas.94.24.13305
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205