Literature DB >> 9371605

The herpes simplex virus virulence factor ICP34.5 and the cellular protein MyD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5, MyD116, and GADD34.

S M Brown1, A R MacLean, E A McKie, J Harland.   

Abstract

The herpes simplex virus (HSV) virulence factor ICP34.5, the mouse myeloid differentiation protein MyD116, and the hamster growth arrest and DNA damage protein GADD34 share a 63-amino-acid carboxyl domain which has significant homologies to otherwise divergent proteins. Here we report that both ICP34.5 and its cellular homolog MyD116 complex through the conserved domain with proliferating cell nuclear antigen. In addition, HSV infection induces a novel 70-kDa cellular protein detectable by antisera to both ICP34.5 and GADD34, demonstrating that this novel protein possesses homology with the 63-amino-acid conserved domain.

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Year:  1997        PMID： 9371605      PMCID： PMC230249     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  45 in total

1.  Polyoma transformation of hamster cell clones--an investigation of genetic factors affecting cell competence.

Authors:  I MACPHERSON; M STOKER
Journal:  Virology       Date:  1962-02       Impact factor: 3.616

2.  Control of protein synthesis in herpesvirus-infected cells: analysis of the polypeptides induced by wild type and sixteen temperature-sensitive mutants of HSV strain 17.

Authors:  H S Marsden; I K Crombie; J H Subak-Sharpe
Journal:  J Gen Virol       Date:  1976-06       Impact factor: 3.891

3.  Isolation and characterization of deletion mutants of herpes simplex virus type 2 (strain HG52).

Authors:  J Harland; S M Brown
Journal:  J Gen Virol       Date:  1985-06       Impact factor: 3.891

4.  The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component.

Authors:  J Chou; B Roizman
Journal:  J Virol       Date:  1986-02       Impact factor: 5.103

5.  The range and distribution of murine central nervous system cells infected with the gamma(1)34.5- mutant of herpes simplex virus 1.

Authors:  N S Markovitz; D Baunoch; B Roizman
Journal:  J Virol       Date:  1997-07       Impact factor: 5.103

6.  Genetic studies with herpes simplex virus type 1. The isolation of temperature-sensitive mutants, their arrangement into complementation groups and recombination analysis leading to a linkage map.

Authors:  S M Brown; D A Ritchie; J H Subak-Sharpe
Journal:  J Gen Virol       Date:  1973-03       Impact factor: 3.891

7.  Temperature-sensitive mutants of herpes simplex virus type 2.

Authors:  M C Timbury
Journal:  J Gen Virol       Date:  1971-11       Impact factor: 3.891

8.  The carboxyl terminus of the murine MyD116 gene substitutes for the corresponding domain of the gamma(1)34.5 gene of herpes simplex virus to preclude the premature shutoff of total protein synthesis in infected human cells.

Authors:  B He; J Chou; D A Liebermann; B Hoffman; B Roizman
Journal:  J Virol       Date:  1996-01       Impact factor: 5.103

9.  Therapy of experimental human brain tumors using a neuroattenuated herpes simplex virus mutant.

Authors:  S Kesari; B P Randazzo; T Valyi-Nagy; Q S Huang; S M Brown; A R MacLean; V M Lee; J Q Trojanowski; N W Fraser
Journal:  Lab Invest       Date:  1995-11       Impact factor: 5.662

10.  Selective vulnerability of mouse CNS neurons to latent infection with a neuroattenuated herpes simplex virus-1.

Authors:  S Kesari; V M Lee; S M Brown; J Q Trojanowski; N W Fraser
Journal:  J Neurosci       Date:  1996-09-15       Impact factor: 6.167
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  30 in total

1.  HSV.com: maneuvering the internetworks of viral neuropathogenesis and evasion of the host defense.

Authors:  S L Tan; M G Katze
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

Review 2.  HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part I. HSV-1 structure, replication and pathogenesis.

Authors:  A Jacobs; X O Breakefield; C Fraefel
Journal:  Neoplasia       Date:  1999-11       Impact factor: 5.715

3.  Signals that dictate nuclear, nucleolar, and cytoplasmic shuttling of the gamma(1)34.5 protein of herpes simplex virus type 1.

Authors:  Guofeng Cheng; Marie-Elena Brett; Bin He
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

4.  Effect of γ34.5 deletions on oncolytic herpes simplex virus activity in brain tumors.

Authors:  Ryuichi Kanai; Cecile Zaupa; Donatella Sgubin; Slawomir J Antoszczyk; Robert L Martuza; Hiroaki Wakimoto; Samuel D Rabkin
Journal:  J Virol       Date:  2012-02-15       Impact factor: 5.103

5.  Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins.

Authors:  H T Adler; R Chinery; D Y Wu; S J Kussick; J M Payne; A J Fornace; D C Tkachuk
Journal:  Mol Cell Biol       Date:  1999-10       Impact factor: 4.272

6.  Intrastrain variants of herpes simplex virus type 1 isolated from a neonate with fatal disseminated infection differ in the ICP34.5 gene, glycoprotein processing, and neuroinvasiveness.

Authors:  J R Bower; H Mao; C Durishin; E Rozenbom; M Detwiler; D Rempinski; T L Karban; K S Rosenthal
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

7.  Herpes simplex virus 2 expresses a novel form of ICP34.5, a major viral neurovirulence factor, through regulated alternative splicing.

Authors:  Shuang Tang; Nini Guo; Amita Patel; Philip R Krause
Journal:  J Virol       Date:  2013-03-13       Impact factor: 5.103

8.  Dephosphorylation of eIF-2alpha mediated by the gamma(1)34.5 protein of herpes simplex virus type 1 is required for viral response to interferon but is not sufficient for efficient viral replication.

Authors:  Guofeng Cheng; Kui Yang; Bin He
Journal:  J Virol       Date:  2003-09       Impact factor: 5.103

9.  Replication of herpes simplex virus 1 depends on the gamma 134.5 functions that facilitate virus response to interferon and egress in the different stages of productive infection.

Authors:  Xianghong Jing; Melissa Cerveny; Kui Yang; Bin He
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103

10.  Regression of human pancreatic tumor xenografts in mice after a single systemic injection of recombinant vaccinia virus GLV-1h68.

Authors:  Yong A Yu; Charles Galanis; Yanghee Woo; Nanhai Chen; Qian Zhang; Yuman Fong; Aladar A Szalay
Journal:  Mol Cancer Ther       Date:  2009-01       Impact factor: 6.261
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