Literature DB >> 9371371

Structure-activity studies of quinolone-penems in genetically defined strains of Escherichia coli.

A F Ehrhardt1, C C Sanders.   

Abstract

Quinolonyl-beta-lactam antimicrobial agents (QLAs) contain quinolones chemically linked to beta-lactams, although the impact of linkage is poorly understood. Genetically defined Escherichia coli strains were used to determine structure-activity characteristics of three quinolone-penem QLAs. Results suggest that the leaving group resulting from beta-lactam hydrolysis may not be free quinolone.

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Year:  1997        PMID： 9371371      PMCID： PMC164166     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

Review 1.  Porins and specific channels of bacterial outer membranes.

Authors:  H Nikaido
Journal:  Mol Microbiol       Date:  1992-02       Impact factor: 3.501

2.  In vitro activity of Ro 24-6392, a novel ester-linked co-drug combining ciprofloxacin and desacetylcefotaxime.

Authors:  R N Jones
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1990-06       Impact factor: 3.267

3.  Resolution of bacterial proteins by polyacrylamide gel electrophoresis on slabs. Membrane, soluble, and periplasmic fractions.

Authors:  G F Ames
Journal:  J Biol Chem       Date:  1974-01-25       Impact factor: 5.157

4.  Cephalosporin 3'-quinolone esters with a dual mode of action.

Authors:  H A Albrecht; G Beskid; K K Chan; J G Christenson; R Cleeland; K H Deitcher; N H Georgopapadakou; D D Keith; D L Pruess; J Sepinwall
Journal:  J Med Chem       Date:  1990-01       Impact factor: 7.446

5.  Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone.

Authors:  H A Albrecht; G Beskid; J G Christenson; K H Deitcher; N H Georgopapadakou; D D Keith; F M Konzelmann; D L Pruess; C C Wei
Journal:  J Med Chem       Date:  1994-02-04       Impact factor: 7.446

6.  Mechanisms of action of cephalosporin 3'-quinolone esters, carbamates, and tertiary amines in Escherichia coli.

Authors:  N H Georgopapadakou; A Bertasso
Journal:  Antimicrob Agents Chemother       Date:  1993-03       Impact factor: 5.191
  6 in total

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