Literature DB >> 9370331

Phosphatidylinositol synthase from mammalian tissues.

B Antonsson1.   

Abstract

Phosphatidylinositol synthase (CDP-diacylglycerol:myo-inositol 3-phosphatidyl-transferase, EC 2.7.8.11) is a 24-kDa membrane-bound enzyme. It is present in all mammalian cells and is localized predominantly to the endoplasmic reticulum. The enzyme performs the last step in the de novo biosynthesis of the phospholipid phosphatidylinositol by catalyzing the condensation of CDP-diacylglycerol and myo-inositol to form the products phosphatidylinositol and CMP. Phosphatidylinositol, apart from being an essential membrane phospholipid, is involved in protein membrane anchoring and is the precursor for the second messengers inositol-tri-phosphate and diacylglycerol.

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Year:  1997        PMID： 9370331     DOI： 10.1016/s0005-2760(97)00105-7

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  26 in total

1.  Phosphatidylinositol synthase and diacylglycerol platforms bust a move.

Authors:  Vytas A Bankaitis; Aby Grabon
Journal:  Dev Cell       Date:  2011-11-15       Impact factor: 12.270

2.  CDP-diacylglycerol phospholipid synthesis in detergent-soluble, non-raft, membrane microdomains of the endoplasmic reticulum.

Authors:  Mark G Waugh; Shane Minogue; Emma L Clayton; J Justin Hsuan
Journal:  J Lipid Res       Date:  2011-09-21       Impact factor: 5.922

3.  CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis.

Authors:  Weijun Pan; Van N Pham; Amber N Stratman; Daniel Castranova; Makoto Kamei; Kameha R Kidd; Brigid D Lo; Kenna M Shaw; Jesus Torres-Vazquez; Constantinos M Mikelis; J Silvio Gutkind; George E Davis; Brant M Weinstein
Journal:  Blood       Date:  2012-05-30       Impact factor: 22.113

Review 4.  The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry).

Authors:  Mark P Thomas; Stephen J Mills; Barry V L Potter
Journal:  Angew Chem Int Ed Engl       Date:  2015-12-22       Impact factor: 15.336

Review 5.  Membrane phospholipid synthesis and endoplasmic reticulum function.

Authors:  Paolo Fagone; Suzanne Jackowski
Journal:  J Lipid Res       Date:  2008-10-23       Impact factor: 5.922

6.  Phosphatidylinositol synthase is required for lens structural integrity and photoreceptor cell survival in the zebrafish eye.

Authors:  Taylor R Murphy; Thomas S Vihtelic; Kristina E Ile; Corey T Watson; Gregory B Willer; Ronald G Gregg; Vytas A Bankaitis; David R Hyde
Journal:  Exp Eye Res       Date:  2011-06-23       Impact factor: 3.467

Review 7.  Mitochondrial phospholipids: role in mitochondrial function.

Authors:  Edgard M Mejia; Grant M Hatch
Journal:  J Bioenerg Biomembr       Date:  2016-04       Impact factor: 2.945

Review 8.  Surfactant phospholipid metabolism.

Authors:  Marianna Agassandian; Rama K Mallampalli
Journal:  Biochim Biophys Acta       Date:  2012-09-29

9.  Genomic analysis of PIS1 gene expression.

Authors:  Mary E Gardocki; Margaret Bakewell; Deepa Kamath; Kelly Robinson; Kathy Borovicka; John M Lopes
Journal:  Eukaryot Cell       Date:  2005-03

Review 10.  The role of phosphoinositides in synapse function.

Authors:  Yoshibumi Ueda
Journal:  Mol Neurobiol       Date:  2014-06-17       Impact factor: 5.590
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