Literature DB >> 9369245

Mechanisms of cycloheximide-induced apoptosis in liver cells.

A V Alessenko1, G N Filippova, A V Khrenov, A S Loginov, E D Makarieva.   

Abstract

Cycloheximide in sublethal doses caused apoptosis in liver cells in vivo, inducing c-myc, c-fos, c-jun and p53 genes and accumulation of sphingosine, a toxic product of the sphingomyelin cycle. These data support the hypothesis that continuous synthesis of labile protective proteins is required to restrain apoptosis in liver; sphingosine might be important in mediating cycloheximide-induced apoptosis as an endogenous modulator of protein kinase C activity.

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Year:  1997        PMID： 9369245     DOI： 10.1016/s0014-5793(97)01161-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  15 in total

1.  Involvement of DNase gamma in apoptotic DNA fragmentation in histiocytic necrotizing lymphadenitis.

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Journal:  Virchows Arch       Date:  2003-06-12       Impact factor: 4.064

2.  Rapid turnover of mcl-1 couples translation to cell survival and apoptosis.

Authors:  Kenneth W Adams; Geoffrey M Cooper
Journal:  J Biol Chem       Date:  2007-01-02       Impact factor: 5.157

3.  Proteomic profiling identified multiple short-lived members of the central proteome as the direct targets of the addicted oncogenes in cancer cells.

Authors:  Tonggang Qi; Wei Zhang; Yun Luan; Feng Kong; Dawei Xu; Guanghui Cheng; Yunshan Wang
Journal:  Mol Cell Proteomics       Date:  2013-10-08       Impact factor: 5.911

4.  Secondary Metabolites from Fungal Endophytes of Echinacea purpurea Suppress Cytokine Secretion by Macrophage-Type Cells.

Authors:  Amninder Kaur; Martina Oberhofer; Monika Juzumaite; Huzefa A Raja; Travis V Gulledge; Diana Kao; Stanley H Faeth; Scott M Laster; Nicholas H Oberlies; Nadja B Cech
Journal:  Nat Prod Commun       Date:  2016-01       Impact factor: 0.986

Review 5.  Pharmacological modulation of cell death in atherosclerosis: a promising approach towards plaque stabilization?

Authors:  Wim Martinet; Dorien M Schrijvers; Guido R Y De Meyer
Journal:  Br J Pharmacol       Date:  2011-09       Impact factor: 8.739

6.  Smac mimetic enables the anticancer action of BCG-stimulated neutrophils through TNF-α but not through TRAIL and FasL.

Authors:  Goodwin Jinesh G; Srinivas Chunduru; Ashish M Kamat
Journal:  J Leukoc Biol       Date:  2012-04-18       Impact factor: 4.962

7.  CYLD deletion triggers nuclear factor-κB-signaling and increases cell death resistance in murine hepatocytes.

Authors:  Toni Urbanik; Bruno Christian Koehler; Laura Wolpert; Christin Elßner; Anna-Lena Scherr; Thomas Longerich; Nicole Kautz; Stefan Welte; Nadine Hövelmeyer; Dirk Jäger; Ari Waisman; Henning Schulze-Bergkamen
Journal:  World J Gastroenterol       Date:  2014-12-07       Impact factor: 5.742

8.  Autophagy of metallothioneins prevents TNF-induced oxidative stress and toxicity in hepatoma cells.

Authors:  Chiara Ullio; Ulf T Brunk; Chiara Urani; Pasquale Melchioretto; Gabriella Bonelli; Francesco M Baccino; Riccardo Autelli
Journal:  Autophagy       Date:  2015       Impact factor: 16.016

9.  Neuroprotective effect of A20 on TNF-induced postischemic apoptosis.

Authors:  Luyang Yu; Hongsheng Miao; Yanan Hou; Bao Zhang; Lihe Guo
Journal:  Neurochem Res       Date:  2006-01       Impact factor: 3.996

10.  Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation.

Authors:  Neeraj K Saxena; Mark A Titus; Xiaokun Ding; Jeffrey Floyd; Shanthi Srinivasan; Shanthi V Sitaraman; Frank A Anania
Journal:  FASEB J       Date:  2004-08-19       Impact factor: 5.191
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