Literature DB >> 9368773

T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs.

J A Smith1, J A Bluestone.   

Abstract

Fc receptor nonbinding anti-CD3 monoclonal antibodies show promise for clinical application, in that they suppress graft rejection without the toxicity associated with conventional anti-CD3 antibody therapy. Recent studies suggest that the mechanism of soluble anti-CD3 antibody mediated immunosuppression involves partial signaling, induced cytokine deviation and Th1 cell inactivation.

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Year:  1997        PMID： 9368773     DOI： 10.1016/s0952-7915(97)80044-1

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  18 in total

1.  Non FcR-binding murine antihuman CD3 monoclonal antibody is capable of productive TCR signalling and induces proliferation in the presence of costimulation.

Authors:  R T Meijer; S L Yong; I J ten Berge; R A van Lier; P T Schellekens
Journal:  Clin Exp Immunol       Date:  2001-03       Impact factor: 4.330

2.  Functional plasticity of an antigen-specific memory CD4 T cell population.

Authors:  Mojgan Ahmadzadeh; Donna L Farber
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-21       Impact factor: 11.205

Review 3.  Lessons learned from more than 1,000 pancreas transplants at a single institution.

Authors:  D E Sutherland; R W Gruessner; D L Dunn; A J Matas; A Humar; R Kandaswamy; S M Mauer; W R Kennedy; F C Goetz; R P Robertson; A C Gruessner; J S Najarian
Journal:  Ann Surg       Date:  2001-04       Impact factor: 12.969

Review 4.  Immunopathogenesis of thyroid eye disease: emerging paradigms.

Authors:  Vibhavari M Naik; Milind N Naik; Robert A Goldberg; Terry J Smith; Raymond S Douglas
Journal:  Surv Ophthalmol       Date:  2010 May-Jun       Impact factor: 6.048

5.  DNA immunization to prevent autoimmune diabetes.

Authors:  B Coon; L L An; J L Whitton; M G von Herrath
Journal:  J Clin Invest       Date:  1999-07       Impact factor: 14.808

6.  Critical roles for IL-4, IL-5, and eosinophils in chronic skin allograft rejection.

Authors:  A Le Moine; V Flamand; F X Demoor; J C Noël; M Surquin; R Kiss; M A Nahori; M Pretolani; M Goldman; D Abramowicz
Journal:  J Clin Invest       Date:  1999-06       Impact factor: 14.808

Review 7.  Programmable hydrogels.

Authors:  Yong Wang
Journal:  Biomaterials       Date:  2018-03-05       Impact factor: 12.479

Review 8.  Initiation and resolution of mucosal inflammation.

Authors:  Melanie A Sherman; Daniel Kalman
Journal:  Immunol Res       Date:  2004       Impact factor: 2.829

9.  Defining the roles of perforin, Fas/FasL, and tumour necrosis factor alpha in T cell induced mucosal damage in the mouse intestine.

Authors:  M Merger; J L Viney; R Borojevic; D Steele-Norwood; P Zhou; D A Clark; R Riddell; R Maric; E R Podack; K Croitoru
Journal:  Gut       Date:  2002-08       Impact factor: 23.059

Review 10.  Treatment of Type 1 diabetes with anti-CD3 monoclonal antibody: induction of immune regulation?

Authors:  Kevan C Herold; Lesley Taylor
Journal:  Immunol Res       Date:  2003       Impact factor: 2.829
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