| Literature DB >> 9367901 |
R Federico1, R Angelini, L Ercolini, G Venturini, A Mattevi, P Ascenzi.
Abstract
Competitive inhibition of swine kidney copper amine oxidase by diuretic, antihypertensive, and anticoagulant drugs, amiloride, clonidine, and gabexate mesylate, respectively, is reported. The affinity of these compounds for swine kidney copper amine oxidase is similar to that observed for inhibitor binding to nitric oxide synthase and trypsin-like serine proteinases. This finding suggests that amiloride, clonidine, and gabexate mesylate should be administrated under careful control, since enzyme cross-inhibition may occur also in vivo.Entities:
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Year: 1997 PMID： 9367901 DOI： 10.1006/bbrc.1997.7630
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575