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Literature DB >> 9367868

Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1.

K Tobiume¹, T Inage, K Takeda, S Enomoto, K Miyazono, H Ichijo.

Abstract

The mouse cDNA for apoptosis signal-regulating kinase 1 (ASK)1 was isolated. The overall amino acid sequence identity between the mouse and the human ASK1 was 91.9%. A database search revealed that the kinase domain of ASK1 is evolutionally well-conserved over species among nematode, fly, mouse and human. Northern blot analysis identified a 6-kb transcript of ASK1 which is expressed in the various mouse adult tissues including heart, brain, lung, liver and kidney. Immunohistochemical analysis of mouse embryos (17 days post coitum) revealed a localized expression of ASK1 in developing skin, cartilage and bone, suggesting a possible role for ASK1 in tissue development during embryogenesis as well as cytokine-induced apoptosis.

Entities: Disease Gene Species

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Year: 1997 PMID： 9367868 DOI： 10.1006/bbrc.1997.7580

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

20 in total

1. Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection.

Authors: Brett Langley; Melissa A D'Annibale; Kyungsun Suh; Issam Ayoub; Aaron Tolhurst; Birgül Bastan; Lichuan Yang; Brian Ko; Marc Fisher; Sunghee Cho; M Flint Beal; Rajiv R Ratan
Journal: J Neurosci Date: 2008-01-02 Impact factor: 6.167

2. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

Authors: M Saitoh; H Nishitoh; M Fujii; K Takeda; K Tobiume; Y Sawada; M Kawabata; K Miyazono; H Ichijo
Journal: EMBO J Date: 1998-05-01 Impact factor: 11.598

3. Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth.

Authors: Qinghang Liu; Benjamin J Wilkins; Yong J Lee; Hidenori Ichijo; Jeffery D Molkentin
Journal: Mol Cell Biol Date: 2006-05 Impact factor: 4.272

Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1.

1. Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection.

2. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

3. Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth.

4. Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.

Review 5. Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance.

6. Stress-Induced Activation of Apoptosis Signal-Regulating Kinase 1 Promotes Osteoarthritis.

Review 7. Redox signaling and cardiac sarcomeres.

8. SCO2 induces p53-mediated apoptosis by Thr845 phosphorylation of ASK-1 and dissociation of the ASK-1-Trx complex.

9. Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon.

10. Elevating calcium in Th2 cells activates multiple pathways to induce IL-4 transcription and mRNA stabilization.