Literature DB >> 9367793

Therapeutic potential and mechanism of action of oligonucleotides and ribozymes.

Y Lavrovsky1, S Chen, A K Roy.   

Abstract

Specific inactivation of gene expression is an attractive approach for rational drug design to combat degenerative diseases and infectious agents. Oligonucleotide-directed triple-helix formation at cis-acting elements of gene promoters, short oligonucleotides containing base sequences that are complementary to the messenger RNA (antisense oligos), and RNA enzymes (ribozymes) that specifically cleave messenger RNA molecules are currently being used both as experimental tools and as therapeutic agents. Mechanisms of action of various oligonucleotide-based drugs, recent developments in the drug-delivery approaches, and future potentials are discussed in this review. Copyright 1997 Academic Press.

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Year:  1997        PMID： 9367793     DOI： 10.1006/bmme.1997.2631

Source DB:  PubMed          Journal:  Biochem Mol Med        ISSN： 1077-3150


  5 in total

1.  Substrate specificity and reaction kinetics of an X-motif ribozyme.

Authors:  Denis Lazarev; Izabela Puskarz; Ronald R Breaker
Journal:  RNA       Date:  2003-06       Impact factor: 4.942

2.  Subcellular trafficking of antisense oligonucleotides and down-regulation of bcl-2 gene expression in human melanoma cells using a fusogenic liposome delivery system.

Authors:  Qiang Hu; Marcel B Bally; Thomas D Madden
Journal:  Nucleic Acids Res       Date:  2002-08-15       Impact factor: 16.971

3.  Polymersome delivery of siRNA and antisense oligonucleotides.

Authors:  Younghoon Kim; Manorama Tewari; J David Pajerowski; Shenshen Cai; Shamik Sen; Jason H Williams; Jason Williams; Shashank R Sirsi; Shashank Sirsi; Gordon J Lutz; Gordon Lutz; Dennis E Discher
Journal:  J Control Release       Date:  2008-11-12       Impact factor: 9.776

4.  Down-regulation of alpha v/beta 3 integrin via misrouting to lysosomes by overexpression of a beta 3Lamp1 fusion protein.

Authors:  Magali Conesa; Annik Prat; John S Mort; Jacques Marvaldi; Jean-Claude Lissitzky; Nabil G Seidah
Journal:  Biochem J       Date:  2003-03-01       Impact factor: 3.857

Review 5.  The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides.

Authors:  Traian V Chirila; Piroska E Rakoczy; Kerryn L Garrett; Xia Lou; Ian J Constable
Journal:  Biomaterials       Date:  2002-01       Impact factor: 12.479
  5 in total

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