OBJECTIVES: To examine the diameter and distensibility of the abdominal aorta in patients with severe alpha 1-antitrypsin deficiency, and to compare the results with those of normal subjects. MATERIAL AND METHODS: Abdominal aortic diameter and stiffness (beta) was measured using echo-tracking sonography in 19 men (mean age 50, range 25-79) and 17 women (mean age 46, range 26-62) with severe alpha 2-antitrypsin deficiency. The results were compared with those of healthy individuals of corresponding age and gender. RESULTS: There was no significant difference in the abdominal aortic diameter between controls and patients with alpha 1-antitrypsin deficiency when corrected for age, sex and body surface area (men p = 0.20, women p = 0.10). Men with alpha 1-antitrypsin deficiency showed significantly lower stiffness in the abdominal aorta compared to controls (p = 0.025), whereas women did not (p = 0.17). CONCLUSIONS: No significant difference in abdominal aortic diameter could be detected in patients with alpha 1-antitrypsin deficiency compared with controls. However, aortic distensibility in men with alpha 1-antitrypsin deficiency is altered. This may reflect early vessel wall abnormality.
OBJECTIVES: To examine the diameter and distensibility of the abdominal aorta in patients with severe alpha 1-antitrypsin deficiency, and to compare the results with those of normal subjects. MATERIAL AND METHODS:Abdominal aortic diameter and stiffness (beta) was measured using echo-tracking sonography in 19 men (mean age 50, range 25-79) and 17 women (mean age 46, range 26-62) with severe alpha 2-antitrypsin deficiency. The results were compared with those of healthy individuals of corresponding age and gender. RESULTS: There was no significant difference in the abdominal aortic diameter between controls and patients with alpha 1-antitrypsin deficiency when corrected for age, sex and body surface area (men p = 0.20, women p = 0.10). Men with alpha 1-antitrypsin deficiency showed significantly lower stiffness in the abdominal aorta compared to controls (p = 0.025), whereas women did not (p = 0.17). CONCLUSIONS: No significant difference in abdominal aortic diameter could be detected in patients with alpha 1-antitrypsin deficiency compared with controls. However, aortic distensibility in men with alpha 1-antitrypsin deficiency is altered. This may reflect early vessel wall abnormality.
Authors: James M Duckers; Dennis J Shale; Robert A Stockley; Nichola S Gale; Bronwen A J Evans; John R Cockcroft; Charlotte E Bolton Journal: Respir Res Date: 2010-12-07
Authors: Sebastian Fähndrich; Frank Biertz; Annika Karch; Björn Kleibrink; Armin Koch; Helmut Teschler; Tobias Welte; Hans-Ulrich Kauczor; Sabina Janciauskiene; Rudolf A Jörres; Timm Greulich; Claus F Vogelmeier; Robert Bals Journal: Respir Res Date: 2017-09-15
Authors: Farouk Dako; Huaqing Zhao; Alexandra Mulvenna; Yogesh Sean Gupta; Scott Simpson; Friedrich Kueppers Journal: Mayo Clin Proc Innov Qual Outcomes Date: 2021-04-30
Authors: Robert Sandhaus; Charlie Strange; Glenda Stone; M Chris Runken; Christopher M Blanchette; Reuben Howden Journal: Int J Chron Obstruct Pulmon Dis Date: 2020-10-05