Literature DB >> 9364000

Association of chromosome 12p genetic polymorphisms with lung adenocarcinoma risk and prognosis.

G Manenti1, L De Gregorio, S Pilotti, F S Falvella, M Incarbone, F Ravagnani, M A Pierotti, T A Dragani.   

Abstract

The mapping near Kras2 of pulmonary adenoma susceptibility 1 (Pas1), a major locus affecting inherited predisposition to lung cancer in mice prompted us to test the homologous human region (12p12) for association with lung adenocarcinoma, by a population-based study. We genotyped 213 lung adenocarcinoma patients and 219 healthy blood donor subjects for five polymorphic markers mapping in the putative region of interest. Three marker polymorphisms, located in a region spanning approximately 700 kb, were significantly associated with lung adenocarcinoma risk. Furthermore, polymorphisms in KRAS2 and PTHLH loci were also associated with tumor prognosis. These results suggest the existence of a human Pas1 homologous locus on chromosome 12p12.

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Year:  1997        PMID： 9364000     DOI： 10.1093/carcin/18.10.1917

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  10 in total

1.  A subset of skin tumor modifier loci determines survival time of tumor-bearing mice.

Authors:  H Nagase; J H Mao; A Balmain
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

2.  Linkage disequilibrium and physical mapping of Pas1 in mice.

Authors:  G Manenti; A Stafford; L De Gregorio; M Gariboldi; F S Falvella; P Avner; T A Dragani
Journal:  Genome Res       Date:  1999-07       Impact factor: 9.043

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Journal:  Med Mol Morphol       Date:  2008-12-24       Impact factor: 2.309

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5.  Detection of codon 12 K-ras mutations in non-neoplastic mucosa from bronchial carina in patients with lung adenocarcinomas.

Authors:  T Urban; S Ricci; C Danel; M Antoine; M Kambouchner; V Godard; R Lacave; J F Bernaudin
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Review 6.  The genetics and biology of KRAS in lung cancer.

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9.  Epigenetic regulation of RhoB loss of expression in lung cancer.

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Journal:  BMC Cancer       Date:  2007-11-30       Impact factor: 4.430

10.  Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume.

Authors:  Patti C Zeidler-Erdely; Michael L Kashon; Lori A Battelli; Shih-Houng Young; Aaron Erdely; Jenny R Roberts; Steven H Reynolds; James M Antonini
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  10 in total

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