Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Xsox17alpha and -beta mediate endoderm formation in Xenopus.

Literature DB >> 9363948

Xsox17alpha and -beta mediate endoderm formation in Xenopus.

C Hudson¹, D Clements, R V Friday, D Stott, H R Woodland.

Abstract

We have isolated two Xenopus relatives of murine Sox17 expressed in gastrula presumptive endoderm. Xsox17alpha and -beta expression can be induced in animal caps by activin, but not by FGF. Ectopic expression of these genes in animal caps induces the expression of endoderm markers; this induction is blocked by overexpression of a fusion of the Xsox17beta HMG domain to the Drosophila Engrailed repressor domain, as is induction of endoderm markers by activin and the expression of endodermal markers in whole embryos and isolated vegetal poles. These experiments, as well as the effects of the mRNAs on embryo phenotypes, suggest that the Xsox17 genes mediate an activin-induced endoderm differentiation pathway in animal caps and are involved in normal endoderm differentiation in embryos.

Entities: Gene Species

Mesh：

Substances：

Year: 1997 PMID： 9363948 DOI： 10.1016/s0092-8674(00)80423-7

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

Keyword Cloud
Cited

93 in total

1. Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps.

Authors: A M O'Reilly; S Pluskey; S E Shoelson; B G Neel
Journal: Mol Cell Biol Date: 2000-01 Impact factor: 4.272

2. JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates.

Authors: Hiroaki Yamanaka; Tetsuo Moriguchi; Norihisa Masuyama; Morioh Kusakabe; Hiroshi Hanafusa; Ritsuko Takada; Shinji Takada; Eisuke Nishida
Journal: EMBO Rep Date: 2001-12-19 Impact factor: 8.807

3. Altered Notch ligand expression in human liver disease: further evidence for a role of the Notch signaling pathway in hepatic neovascularization and biliary ductular defects.

Authors: Sarbjit S Nijjar; Lorraine Wallace; Heather A Crosby; Stefan G Hubscher; Alastair J Strain
Journal: Am J Pathol Date: 2002-05 Impact factor: 4.307

4. Sox17 and chordin are required for formation of Kupffer's vesicle and left-right asymmetry determination in zebrafish.

Authors: Emil Aamar; Igor B Dawid
Journal: Dev Dyn Date: 2010-11 Impact factor: 3.780

Xsox17alpha and -beta mediate endoderm formation in Xenopus.

1. Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps.

2. JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates.

3. Altered Notch ligand expression in human liver disease: further evidence for a role of the Notch signaling pathway in hepatic neovascularization and biliary ductular defects.

4. Sox17 and chordin are required for formation of Kupffer's vesicle and left-right asymmetry determination in zebrafish.

5. Generation of functional hepatic cells from pluripotent stem cells.

Review 6. Nuclear reprogramming and stem cell creation.

7. Xenopus Nanos1 is required to prevent endoderm gene expression and apoptosis in primordial germ cells.

8. Repression of zygotic gene expression in the Xenopus germline.

9. SRY-box containing gene 17 regulates the Wnt/β-catenin signaling pathway in oligodendrocyte progenitor cells.

10. Characterization of the nutritional endoderm in the direct developing frog Eleutherodactylus coqui.