Literature DB >> 9359719

Simian immunodeficiency virus burden in tissues and cellular compartments during clinical latency and AIDS.

T A Reinhart1, M J Rogan, D Huddleston, D M Rausch, L E Eiden, A T Haase.   

Abstract

In the course of human immunodeficiency virus infection or of the related simian immunodeficiency virus (SIV), progression to AIDS is associated with high virus burdens in blood. How virus burden in the bloodstream is related to virus burden in tissue reservoirs was addressed in an animal model of rhesus macaques infected with SIV. In situ hybridization and quantitative image analysis were used to quantitate virus burden. Animals who developed AIDS had high levels of virus production and storage in lymphoid tissue reservoirs and evidence of productive infection of macrophages in the nervous system. With the quantitative approach described, it should be possible to design and assess the impact of treatment and shed light on the outstanding issues in pathogenesis.

Entities:  

Mesh：

Year:  1997        PMID： 9359719     DOI： 10.1086/514113

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  34 in total

Review 1.  Surrogacy in antiviral drug development.

Authors:  Sunil Shaunak; Donald S Davies
Journal:  Br J Clin Pharmacol       Date:  2002-07       Impact factor: 4.335

2.  Highly uneven distribution of tenofovir-selected simian immunodeficiency virus in different anatomical sites of rhesus macaques.

Authors:  Magdalena Magierowska; Flavien Bernardin; Seema Garg; Silvija Staprans; Michael D Miller; Koen K A Van Rompay; Eric L Delwart
Journal:  J Virol       Date:  2004-03       Impact factor: 5.103

3.  Tissue sites of persistent infection and active replication of equine infectious anemia virus during acute disease and asymptomatic infection in experimentally infected equids.

Authors:  S M Harrold; S J Cook; R F Cook; K E Rushlow; C J Issel; R C Montelaro
Journal:  J Virol       Date:  2000-04       Impact factor: 5.103

4.  The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages.

Authors:  Lara Vojnov; Mauricio A Martins; Alexander T Bean; Marlon G Veloso de Santana; Jonah B Sacha; Nancy A Wilson; Myrna C Bonaldo; Ricardo Galler; Mario Stevenson; David I Watkins
Journal:  J Virol       Date:  2012-02-08       Impact factor: 5.103

Review 5.  Targeting early infection to prevent HIV-1 mucosal transmission.

Authors:  Ashley T Haase
Journal:  Nature       Date:  2010-03-11       Impact factor: 49.962

6.  Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption.

Authors:  Meghan K Rothenberger; Brandon F Keele; Stephen W Wietgrefe; Courtney V Fletcher; Gregory J Beilman; Jeffrey G Chipman; Alexander Khoruts; Jacob D Estes; Jodi Anderson; Samuel P Callisto; Thomas E Schmidt; Ann Thorkelson; Cavan Reilly; Katherine Perkey; Thomas G Reimann; Netanya S Utay; Krystelle Nganou Makamdop; Mario Stevenson; Daniel C Douek; Ashley T Haase; Timothy W Schacker
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-23       Impact factor: 11.205

Review 7.  Tissue issues: mucosal T-cell responses in HIV-1 infection.

Authors:  Barbara L Shacklett; April L Ferre; Brenna E Kiniry
Journal:  Curr Opin HIV AIDS       Date:  2019-03       Impact factor: 4.283

8.  Identification of T lymphocytes in simian immunodeficiency virus encephalitis: distribution of CD8+ T cells in association with central nervous system vessels and virus.

Authors:  Woong-Ki Kim; Sarah Corey; Gillian Chesney; Heather Knight; Sherry Klumpp; Christian Wüthrich; Norman Letvin; Igor Koralnik; Andrew Lackner; Ronald Veasey; Kenneth Williams
Journal:  J Neurovirol       Date:  2004-10       Impact factor: 2.643

9.  Suppression of HIV-1 Infectivity by Human Glioma Cells.

Authors:  Sheikh Ariful Hoque; Atsushi Tanaka; Salequl Islam; Gias Uddin Ahsan; Atsushi Jinno-Oue; Hiroo Hoshino
Journal:  AIDS Res Hum Retroviruses       Date:  2016-01-07       Impact factor: 2.205

10.  HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads.

Authors:  Susanna L Lamers; Rebecca Rose; Ekaterina Maidji; Melissa Agsalda-Garcia; David J Nolan; Gary B Fogel; Marco Salemi; Debra L Garcia; Paige Bracci; William Yong; Deborah Commins; Jonathan Said; Negar Khanlou; Charles H Hinkin; Miguel Valdes Sueiras; Glenn Mathisen; Suzanne Donovan; Bruce Shiramizu; Cheryl A Stoddart; Michael S McGrath; Elyse J Singer
Journal:  J Virol       Date:  2016-09-29       Impact factor: 5.103
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