| Literature DB >> 9359698 |
R Chinery1, J A Brockman, M O Peeler, Y Shyr, R D Beauchamp, R J Coffey.
Abstract
Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States. Five-fluorouracil (5FU) remains the single most effective treatment for advanced disease, despite a response rate of only 20%. Herein, we show that the antioxidants pyrrolidinedithiocarbamate and vitamin E induce apoptosis in CRC cells. This effect is mediated by induction of p21WAF1/CIP1, a powerful inhibitor of the cell cycle, through a mechanism involving C/EBPbeta (a member of the CCAAT/enhancer binding protein family of transcription factors), independent of p53. Antioxidants significantly enhance CRC tumor growth inhibition by cytotoxic chemotherapy in vitro (5FU and doxorubicin) and in vivo (5FU). Thus, chemotherapeutic agents administered in the presence of antioxidants may provide a novel therapy for colorectal cancer.Entities:
Mesh：
Substances：
Year: 1997 PMID： 9359698 DOI： 10.1038/nm1197-1233
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440