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Literature DB >> 935870

Morphine analgesic tolerance: its situation specificity supports a Pavlovian conditioning model.

Abstract

Rats were made tolerant to morphine in either of two environments and then assessed for morphine-induced alteration of pain sensitivity in both environments. Analgesic tolerance was displayed when rats were tested in that environment in which they previously received morphine, but not in the alternative environment. The results indicate than an association between environmental cues and the systemic effects of morphine is crucial to tolerance development.

Entities: Chemical Disease Species

Mesh：

Substances：
Morphine

Year: 1976 PMID： 935870 DOI： 10.1126/science.935870

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

46 in total

1. The role of blocking and compensatory conditioning in the treatment preexposure effect.

Authors: N S Braveman
Journal: Psychopharmacology (Berl) Date: 1979-03-22 Impact factor: 4.530

2. Conditioned temperature effects using morphine as the unconditioned stimulus.

Authors: R Eikelboom; J Stewart
Journal: Psychopharmacology (Berl) Date: 1979-03-14 Impact factor: 4.530

3. Situational specificity of tolerance to effects of phencyclidine on responding of rats under fixed-ratio and spaced-responding schedules.

Authors: J B Smith
Journal: Psychopharmacology (Berl) Date: 1991 Impact factor: 4.530

4. Conditioned morphine withdrawal in the hamster.

Authors: P Schnur
Journal: Psychopharmacology (Berl) Date: 1992 Impact factor: 4.530

5. Discrete cues paired with naloxone-precipitated withdrawal from acute morphine dependence elicit conditioned withdrawal responses.

Authors: Nurith Amitai; Jian Liu; Gery Schulteis
Journal: Behav Pharmacol Date: 2006-05 Impact factor: 2.293

Morphine analgesic tolerance: its situation specificity supports a Pavlovian conditioning model.

1. The role of blocking and compensatory conditioning in the treatment preexposure effect.

2. Conditioned temperature effects using morphine as the unconditioned stimulus.

3. Situational specificity of tolerance to effects of phencyclidine on responding of rats under fixed-ratio and spaced-responding schedules.

4. Conditioned morphine withdrawal in the hamster.

5. Discrete cues paired with naloxone-precipitated withdrawal from acute morphine dependence elicit conditioned withdrawal responses.

6. Conditional tolerance to haloperidol-induced catalepsy is not caused by striatal dopamine receptor supersensitivity.

7. An fMRI investigation of the impact of withdrawal on regional brain activity during nicotine anticipation.

8. Learning and the wisdom of the body.

9. Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor.

10. Alcohol is an effective cue in the conditional control of tolerance to alcohol.