Literature DB >> 935866

Radioimmunoassay for colchicine in plasma and urine.

N H Ertel, J C Mittler, S Akgun, S L Wallace.   

Abstract

A radioimmunoassay for the measurement of colchicine (in quantities as small as 0.05 nanogram) in plasma and urine was developed with the use of an antibody from immunized rabbits. After the intravenous injection of 2 milligrams of colchicine in seven subjects, the calculated zero-time concentration in the plasma was 2.9 +/- 1.5 micrograms per deciliter, and the mean half-time in the plasma was 58 +/- 20 minutes. Declining, but measurable, amounts of colchicine could be detected in urine up to day 9 after the drug was administered.

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Year:  1976        PMID： 935866     DOI： 10.1126/science.935866

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

1.  Pharmacokinetics/bioavailability of colchicine in healthy male volunteers.

Authors:  G Achtert; J M Scherrmann; M O Christen
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1989 Oct-Dec       Impact factor: 2.441

2.  Zero-order absorption and linear disposition of oral colchicine in healthy volunteers.

Authors:  G Thomas; C Girre; J M Scherrmann; P Francheteau; J L Steimer
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

3.  Pharmacokinetics and absolute bioavailability of colchicine after i.v. and oral administration in healthy human volunteers and elderly subjects.

Authors:  M Rochdi; A Sabouraud; C Girre; R Venet; J M Scherrmann
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953

4.  Structural analysis of human neutrophil migration. Centriole, microtubule, and microfilament orientation and function during chemotaxis.

Authors:  H L Malech; R K Root; J I Gallin
Journal:  J Cell Biol       Date:  1977-12       Impact factor: 10.539
  4 in total

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