Literature DB >> 935865

Mevalonate metabolism: role of kidneys.

J Edmond, A M Fogelman, G Popják.   

Abstract

More than one-half of the amount of mevalonate that is metabolized by pathways not leading to sterols is accounted for by the action of the kidneys. Conversion of mevalonate in vivo to squalene and sterols in the kidneys is confined almost entirely to the proximal and distal convoluted tubules in the cortex. More sterol than squalene is synthesized from mevalonate not only in the liver but also in the kidney.

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Year:  1976        PMID： 935865     DOI： 10.1126/science.935865

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  6 in total

1.  Regulation of [beta]-Methylcrotonyl-Coenzyme A Carboxylase Activity by Biotinylation of the Apoenzyme.

Authors:  X. Wang; E. S. Wurtele; B. J. Nikolau
Journal:  Plant Physiol       Date:  1995-07       Impact factor: 8.340

Review 2.  "As I remember it" research on biosynthesis of fatty acids, triglycerides, squalene, and cholesterol.

Authors:  G Popják
Journal:  J Am Oil Chem Soc       Date:  1977-08       Impact factor: 1.849

Review 3.  The contribution of the cholesterol biosynthetic pathway to intermediary metabolism and cell function.

Authors:  R Fears
Journal:  Biochem J       Date:  1981-10-01       Impact factor: 3.857

4.  The effect of diabetes on mevalonate metabolism in the rat.

Authors:  M H Wiley; K R Feingold; M M Howton; M D Siperstein
Journal:  Diabetologia       Date:  1982-02       Impact factor: 10.122

5.  (R)-mevalonate excretion in human and rat urines.

Authors:  R R Kopito; H Brunengraber
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205

6.  Sex difference in human mevalonate metabolism.

Authors:  K R Feingold; M H Wiley; G L Searle; B K Machida; M D Siperstein
Journal:  J Clin Invest       Date:  1980-08       Impact factor: 14.808
  6 in total

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