| Literature DB >> 9358642 |
O Shirota1, K Takizawa, S Sekita, M Satake, Y Hirayama, Y Hakamata, T Hayashi, T Yanagawa.
Abstract
The isolation and structure elucidation of five novel natural Diels--Alder-type adducts, named palodesangrens A-E (1-5), from the Peruvian folk medicine known as "palo de sangre" (Brosimum rubescens) is described. The structures of the Diels--Alder adducts, consisting of chalcone derivatives and a prenylcoumarin, were elucidated by analysis of spectroscopic data including 2D NMR. Some of these compounds showed potent inhibitory activity towards 5 alpha-dihydrotestosterone (DHT) binding with an androgen receptor to form a DHT-receptor complex that causes androgen-dependent diseases.Entities:
Mesh：
Substances：
Year: 1997 PMID： 9358642 DOI： 10.1021/np9607215
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050