Literature DB >> 9357512

Dibasic benzo[b]thiophene derivatives as a novel class of active site-directed thrombin inhibitors. 1. Determination of the serine protease selectivity, structure-activity relationships, and binding orientation.

D J Sall1, J A Bastian, S L Briggs, J A Buben, N Y Chirgadze, D K Clawson, M L Denney, D D Giera, D S Gifford-Moore, R W Harper, K L Hauser, V J Klimkowski, T J Kohn, H S Lin, J R McCowan, A D Palkowitz, G F Smith, K Takeuchi, K J Thrasher, J M Tinsley, B G Utterback, S C Yan, M Zhang.   

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Year:  1997        PMID: 9357512     DOI: 10.1021/jm9704107

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


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  4 in total

Review 1.  Finding a better path to drug selectivity.

Authors:  Yuko Kawasaki; Ernesto Freire
Journal:  Drug Discov Today       Date:  2011-08-02       Impact factor: 7.851

2.  The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: a binding mode for a structurally novel class of inhibitors.

Authors:  N Y Chirgadze; D J Sall; S L Briggs; D K Clawson; M Zhang; G F Smith; R W Schevitz
Journal:  Protein Sci       Date:  2000-01       Impact factor: 6.725

3.  In Silico Study Reveals How E64 Approaches, Binds to, and Inhibits Falcipain-2 of Plasmodium falciparum that Causes Malaria in Humans.

Authors:  Emmanuel Oluwatobi Salawu
Journal:  Sci Rep       Date:  2018-11-06       Impact factor: 4.379

4.  Transition-metal/Lewis acid free synthesis of acyl benzothiophenes via C-C bond forming reaction.

Authors:  Sarbani Pal; Mohammad Ashrafuddin Khan; P Bindu; P K Dubey
Journal:  Beilstein J Org Chem       Date:  2007-10-25       Impact factor: 2.883

  4 in total

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