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Literature DB >> 9356487

Dendritic cell ontogeny: a human dendritic cell lineage of myeloid origin.

J Olweus¹, A BitMansour, R Warnke, P A Thompson, J Carballido, L J Picker, F Lund-Johansen.

Abstract

Dendritic cells (DC) have been thought to represent a family of closely related cells with similar functions and developmental pathways. The best-characterized precursors are the epidermal Langerhans cells, which migrate to lymphoid organs and become activated DC in response to inflammatory stimuli. Here, we demonstrate that a large subset of DC in the T cell-dependent areas of human lymphoid organs are nonactivated cells and belong to a separate lineage that can be identified by high levels of the interleukin 3 receptor alpha chain (IL-3Ralphahi). The CD34+IL-3Ralphahi DC progenitors are of myeloid origin and are distinct from those that give rise to Langerhans cells in vitro. The IL-3Ralphahi DC furthermore appear to migrate to lymphoid organs independently of inflammatory stimuli or foreign antigens. Thus, DC are heterogeneous with regard to function and ontogeny.

Entities: Gene Species

Mesh：

Substances：

Year: 1997 PMID： 9356487 PMCID： PMC25034 DOI： 10.1073/pnas.94.23.12551

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

43 in total

1. CD34+CD38dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells.

Authors: P Res; E Martínez-Cáceres; A Cristina Jaleco; F Staal; E Noteboom; K Weijer; H Spits
Journal: Blood Date: 1996-06-15 Impact factor: 22.113

2. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells.

Authors: L J Zhou; T F Tedder
Journal: Proc Natl Acad Sci U S A Date: 1996-03-19 Impact factor: 11.205

Review 3. The instructive role of innate immunity in the acquired immune response.

Authors: D T Fearon; R M Locksley
Journal: Science Date: 1996-04-05 Impact factor: 47.728

4. New insights into the mobilization and phagocytic activity of dendritic cells.

Authors: J M Austyn
Journal: J Exp Med Date: 1996-04-01 Impact factor: 14.307

5. Interleukin-3 cooperates with tumor necrosis factor alpha for the development of human dendritic/Langerhans cells from cord blood CD34+ hematopoietic progenitor cells.

Authors: C Caux; B Vanbervliet; C Massacrier; I Durand; J Banchereau
Journal: Blood Date: 1996-03-15 Impact factor: 22.113

6. The interaction of macrophage and non-macrophage tropic isolates of HIV-1 with thymic and tonsillar dendritic cells in vitro.

Authors: P U Cameron; M G Lowe; F Sotzik; A F Coughlan; S M Crowe; K Shortman
Journal: J Exp Med Date: 1996-04-01 Impact factor: 14.307

7. A life stage of particle-laden rat dendritic cells in vivo: their terminal division, active phagocytosis, and translocation from the liver to the draining lymph.

Authors: K Matsuno; T Ezaki; S Kudo; Y Uehara
Journal: J Exp Med Date: 1996-04-01 Impact factor: 14.307

8. CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha.

Authors: C Caux; B Vanbervliet; C Massacrier; C Dezutter-Dambuyant; B de Saint-Vis; C Jacquet; K Yoneda; S Imamura; D Schmitt; J Banchereau
Journal: J Exp Med Date: 1996-08-01 Impact factor: 14.307

9. Identification of dendritic cell colony-forming units among normal human CD34+ bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha.

Authors: J W Young; P Szabolcs; M A Moore
Journal: J Exp Med Date: 1995-10-01 Impact factor: 14.307

10. Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1.

Authors: J A Roake; A S Rao; P J Morris; C P Larsen; D F Hankins; J M Austyn
Journal: J Exp Med Date: 1995-06-01 Impact factor: 14.307

69 in total

1. Extensive characterization of the immunophenotype and pattern of cytokine production by distinct subpopulations of normal human peripheral blood MHC II+/lineage- cells.

Authors: J Almeida; C Bueno; M C Alguero; M L Sanchez; M C Cañizo; M E Fernandez; J M Vaquero; F J Laso; L Escribano; J F San Miguel; A Orfao
Journal: Clin Exp Immunol Date: 1999-12 Impact factor: 4.330

10. The cross-regulatory relationship between human dendritic and regulatory T cells and its role in type 1 diabetes mellitus.

Authors: Hsuen-Wen Chang; Yen-Hung Chow; Pele Chong; Charles Sia
Journal: Rev Diabet Stud Date: 2007-08-10

Dendritic cell ontogeny: a human dendritic cell lineage of myeloid origin.

1. CD34+CD38dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells.

2. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells.

Review 3. The instructive role of innate immunity in the acquired immune response.

4. New insights into the mobilization and phagocytic activity of dendritic cells.

5. Interleukin-3 cooperates with tumor necrosis factor alpha for the development of human dendritic/Langerhans cells from cord blood CD34+ hematopoietic progenitor cells.

6. The interaction of macrophage and non-macrophage tropic isolates of HIV-1 with thymic and tonsillar dendritic cells in vitro.

7. A life stage of particle-laden rat dendritic cells in vivo: their terminal division, active phagocytosis, and translocation from the liver to the draining lymph.

8. CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha.

9. Identification of dendritic cell colony-forming units among normal human CD34+ bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha.

10. Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1.

1. Extensive characterization of the immunophenotype and pattern of cytokine production by distinct subpopulations of normal human peripheral blood MHC II+/lineage- cells.

Review 2. Dendritic cells: a link between innate and adaptive immunity.

3. Phenotypic characterization of five dendritic cell subsets in human tonsils.

4. The role of pDC, recipient T(reg) and donor T(reg) in HSC engraftment: Mechanisms of facilitation.

Review 5. The plasmacytoid monocyte/interferon producing cells.

6. Interleukin-12: an update on its immunological activities, signaling and regulation of gene expression.

7. Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines.

8. A cytotoxic anti-IL-3Rα antibody targets key cells and cytokines implicated in systemic lupus erythematosus.

9. Characterization of virus-responsive plasmacytoid dendritic cells in the rhesus macaque.

10. The cross-regulatory relationship between human dendritic and regulatory T cells and its role in type 1 diabetes mellitus.