Literature DB >> 9356447

Peptide nucleic acid-DNA duplexes: long range hole migration from an internally linked anthraquinone.

B Armitage1, D Ly, T Koch, H Frydenlund, H Orum, H G Batz, G B Schuster.   

Abstract

The discovery that peptide nucleic acids (PNA) mimic DNA and RNA by forming complementary duplex structures following Watson-Crick base pairing rules opens fields in biochemistry, diagnostics, and medicine for exploration. Progress requires the development of modified PNA duplexes having unique and well defined properties. We find that anthraquinone groups bound to internal positions of a PNA oligomer intercalate in the PNA-DNA hybrid. Their irradiation with near-UV light leads to electron transfer and oxidative damage at remote GG doublets on the complementary DNA strand. This behavior mimics that observed in related DNA duplexes and provides the first evidence for long range electron (hole) transport in PNA-DNA hybrid. Analysis of the mechanism for electron transport supports hole hopping.

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Year:  1997        PMID： 9356447      PMCID： PMC24924          DOI： 10.1073/pnas.94.23.12320

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

1.  Solid-phase synthesis of peptide nucleic acids.

Authors:  L Christensen; R Fitzpatrick; B Gildea; K H Petersen; H F Hansen; T Koch; M Egholm; O Buchardt; P E Nielsen; J Coull; R H Berg
Journal:  J Pept Sci       Date:  1995 May-Jun       Impact factor: 1.905

2.  PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules.

Authors:  M Egholm; O Buchardt; L Christensen; C Behrens; S M Freier; D A Driver; R H Berg; S K Kim; B Norden; P E Nielsen
Journal:  Nature       Date:  1993-10-07       Impact factor: 49.962

3.  Formation of 8-hydroxy(deoxy)guanosine and generation of strand breaks at guanine residues in DNA by singlet oxygen.

Authors:  T P Devasagayam; S Steenken; M S Obendorf; W A Schulz; H Sies
Journal:  Biochemistry       Date:  1991-06-25       Impact factor: 3.162

4.  Methylene blue plus light mediates 8-hydroxyguanine formation in DNA.

Authors:  R A Floyd; M S West; K L Eneff; J E Schneider
Journal:  Arch Biochem Biophys       Date:  1989-08-15       Impact factor: 4.013

5.  Induction of strand breaks in polyribonucleotides and DNA by the sulphate radical anion: role of electron loss centres as precursors of strand breakage.

Authors:  P Wolf; G D Jones; L P Candeias; P O'Neill
Journal:  Int J Radiat Biol       Date:  1993-07       Impact factor: 2.694

6.  8-Hydroxydeoxyguanosine formation at the 5' site of 5'-GG-3' sequences in double-stranded DNA by UV radiation with riboflavin.

Authors:  K Ito; S Inoue; K Yamamoto; S Kawanishi
Journal:  J Biol Chem       Date:  1993-06-25       Impact factor: 5.157

7.  X-ray structure of a DNA decamer containing 7,8-dihydro-8-oxoguanine.

Authors:  L A Lipscomb; M E Peek; M L Morningstar; S M Verghis; E M Miller; A Rich; J M Essigmann; L D Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1995-01-31       Impact factor: 11.205

8.  Interactions of DNA binding ligands with PNA-DNA hybrids.

Authors:  P Wittung; S K Kim; O Buchardt; P Nielsen; B Nordèn
Journal:  Nucleic Acids Res       Date:  1994-12-11       Impact factor: 16.971

9.  193 nm light induces single strand breakage of DNA predominantly at guanine.

Authors:  T Melvin; M A Plumb; S W Botchway; P O'Neill; A W Parker
Journal:  Photochem Photobiol       Date:  1995-06       Impact factor: 3.421

10.  Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide.

Authors:  P E Nielsen; M Egholm; R H Berg; O Buchardt
Journal:  Science       Date:  1991-12-06       Impact factor: 47.728
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  5 in total

1.  Long-distance charge transport in duplex DNA: the phonon-assisted polaron-like hopping mechanism.

Authors:  P T Henderson; D Jones; G Hampikian; Y Kan; G B Schuster
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-20       Impact factor: 11.205

2.  Enzymatic reaction with unnatural substrates: DNA photolyase (Escherichia coli) recognizes and reverses thymine [2+2] dimers in the DNA strand of a DNA/PNA hybrid duplex.

Authors:  D Ramaiah; Y Kan; T Koch; H Orum; G B Schuster
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-27       Impact factor: 11.205

3.  Peptide nucleic acid (PNA)/DNA hybrid duplexes: intercalation by an internally linked anthraquinone.

Authors:  B Armitage; T Koch; H Frydenlund; H Orum; G B Schuster
Journal:  Nucleic Acids Res       Date:  1998-02-01       Impact factor: 16.971

4.  Methods for assessing DNA hybridization of peptide nucleic acid-titanium dioxide nanoconjugates.

Authors:  Eric M B Brown; Tatjana Paunesku; AiGuo Wu; K Ted Thurn; Benjamin Haley; Jimmy Clark; Taisa Priester; Gayle E Woloschak
Journal:  Anal Biochem       Date:  2008-08-26       Impact factor: 3.365

5.  On the stability of peptide nucleic acid duplexes in the presence of organic solvents.

Authors:  Anjana Sen; Peter E Nielsen
Journal:  Nucleic Acids Res       Date:  2007-05-03       Impact factor: 16.971
  5 in total

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