Literature DB >> 9354230

Inhibition of the Ser-Thr phosphatases PP1 and PP2A by naturally occurring toxins.

J E Sheppeck1, C M Gauss, A R Chamberlin.   

Abstract

The okadaic acid class of naturally occurring toxins is a structurally diverse group of molecules that inhibit the protein phosphatases PP1 and PP2A. Studies providing information about the mode of binding between the toxins and the phosphatases contribute to an overall understanding of the signal transduction pathways in which the phosphatases are involved.

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Year:  1997        PMID： 9354230     DOI： 10.1016/s0968-0896(97)00146-6

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  23 in total

Review 1.  The role of serine/threonine protein phosphatases in exocytosis.

Authors:  Alistair T R Sim; Monique L Baldwin; John A P Rostas; Jeff Holst; Russell I Ludowyke
Journal:  Biochem J       Date:  2003-08-01       Impact factor: 3.857

2.  Discovery of protein phosphatase 2C inhibitors by virtual screening.

Authors:  Jessica P Rogers; Albert E Beuscher; Marc Flajolet; Thomas McAvoy; Angus C Nairn; Arthur J Olson; Paul Greengard
Journal:  J Med Chem       Date:  2006-03-09       Impact factor: 7.446

3.  Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition.

Authors:  Brian G Lawhorn; Sobhana B Boga; Scott E Wolkenberg; David A Colby; Carla-Maria Gauss; Mark R Swingle; Lauren Amable; Richard E Honkanen; Dale L Boger
Journal:  J Am Chem Soc       Date:  2006-12-27       Impact factor: 15.419

4.  NMDA Receptors and Oxidative Stress Induced by the Major Metabolites Accumulating in HMG Lyase Deficiency Mediate Hypophosphorylation of Cytoskeletal Proteins in Brain From Adolescent Rats: Potential Mechanisms Contributing to the Neuropathology of This Disease.

Authors:  Carolina Gonçalves Fernandes; Paula Pierozan; Gilberto Machado Soares; Fernanda Ferreira; Ângela Zanatta; Alexandre Umpierrez Amaral; Clarissa Günther Borges; Moacir Wajner; Regina Pessoa-Pureur
Journal:  Neurotox Res       Date:  2015-07-15       Impact factor: 3.911

5.  Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1).

Authors:  Yanshan Fang; Sriram Sathyanarayanan; Amita Sehgal
Journal:  Genes Dev       Date:  2007-06-15       Impact factor: 11.361

6.  GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA.

Authors:  Qing-Rong Liu; Ping-Wu Zhang; Zhicheng Lin; Qi-Fu Li; Amina S Woods; Juan Troncoso; George R Uhl
Journal:  Biochem J       Date:  2004-01-01       Impact factor: 3.857

7.  PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation.

Authors:  Seth S Margolis; Susan Walsh; Douglas C Weiser; Minoru Yoshida; Shirish Shenolikar; Sally Kornbluth
Journal:  EMBO J       Date:  2003-11-03       Impact factor: 11.598

8.  A structural mechanism for maintaining the 'on-state' of the CaMKII memory switch in the post-synaptic density.

Authors:  Praseeda Mullasseril; Ayse Dosemeci; John E Lisman; Leslie C Griffith
Journal:  J Neurochem       Date:  2007-10       Impact factor: 5.372

9.  Dictyostelium discoideum protein phosphatase-1 catalytic subunit exhibits distinct biochemical properties.

Authors:  Luiz P M Andrioli; Paulo A Zaini; Wladia Viviani; Aline M Da Silva
Journal:  Biochem J       Date:  2003-08-01       Impact factor: 3.857

Review 10.  Calyculins and related marine natural products as serine-threonine protein phosphatase PP1 and PP2A inhibitors and total syntheses of calyculin A, B, and C.

Authors:  Annika E Fagerholm; Damien Habrant; Ari M P Koskinen
Journal:  Mar Drugs       Date:  2010-01-21       Impact factor: 5.118
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