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Literature DB >> 9353596

Immobilization stress increases mRNA levels of interleukin-1 receptor antagonist in various rat brain regions.

E Suzuki¹, F Shintani, S Kanba, M Asai, T Nakaki.

Abstract

1. Interleukin-1 receptor antagonist (IL-1Ra), as well as the interleukin-1 beta (IL-1 beta) gene response to immobilization stress (IMS), was examined in the rat brain. The reverse transcription-polymerase chain reaction was employed to determine mRNA levels. 3. IL-1 beta and IL-1Ra mRNA levels peaked at approximately 0.5 and 2-4 hr, respectively. The maximum mRNA levels of IL-1 beta were 15-fold higher than pre-IMS levels, whereas those of IL-1Ra were 250-fold higher in the hypothalamus. 3. After the biosynthesis of IL-1 beta has peaked, IL-1Ra may contribute to attenuation of the IL-1 activity which has been enhanced by IMS.

Entities: Disease Gene Species

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Year: 1997 PMID： 9353596 DOI： 10.1023/a:1026319107528

Source DB: PubMed Journal: Cell Mol Neurobiol ISSN： 0272-4340 Impact factor: 5.046

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Immobilization stress increases mRNA levels of interleukin-1 receptor antagonist in various rat brain regions.

Review 1. Sickness behavior as a new target for drug development.

Review 2. The interleukin-1 family: 10 years of discovery.

3. Immobilization stress induces interleukin-1 beta mRNA in the rat hypothalamus.

4. Immunoreactive interleukin-1 beta localization in the rat forebrain.

5. Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA.

6. Involvement of interleukin-1 in immobilization stress-induced increase in plasma adrenocorticotropic hormone and in release of hypothalamic monoamines in the rat.

7. Induction of interleukin-1 beta mRNA in adult rat brain.

Review 8. Interleukin-1 receptor antagonist.

9. Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism.

10. Localization of interleukin-1 receptor antagonist mRNA in rat brain.

Review 1. Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse.

2. Rat strain differences in restraint stress-induced brain cytokines.

3. Repeated exposure to two stressors in sequence demonstrates that corticosterone and paraventricular nucleus of the hypothalamus interleukin-1β responses habituate independently.

4. Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety.

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