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Literature DB >> 9353230

Poxviruses as expression vectors.

Abstract

Poxviruses are widely used for the cytoplasmic expression of recombinant genes in mammalian cells. Recent improvements allow high expression and simplify the integration of multiple foreign genes. Vaccinia virus mutants and other poxviruses that undergo abortive infection in mammalian cells are receiving special attention because of their diminished cytopathic effects and increased safety. New replicating and 'non-replicating' vectors, encoding the bacteriophage T7 RNA polymerase for transcription of recombinant genes, have been engineered.

Entities: Disease Species

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Year: 1997 PMID： 9353230 DOI： 10.1016/s0958-1669(97)80031-6

Source DB: PubMed Journal: Curr Opin Biotechnol ISSN： 0958-1669 Impact factor: 9.740

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Cited

22 in total

1. Recombinant vaccinia viruses. Design, generation, and isolation.

Authors: C C Broder; P L Earl
Journal: Mol Biotechnol Date: 1999-12-15 Impact factor: 2.695

2. Vaccinia virus-specific CD8(+) T-cell responses target a group of epitopes without a strong immunodominance hierarchy in humans.

Authors: Masanori Terajima; Laura Orphin; Anita M Leporati; Pamela Pazoles; John Cruz; Alan L Rothman; Francis A Ennis
Journal: Hum Immunol Date: 2008-10-26 Impact factor: 2.850

3. Primary Human B Cells at Different Differentiation and Maturation Stages Exhibit Distinct Susceptibilities to Vaccinia Virus Binding and Infection.

Authors: Nicole Shepherd; Jie Lan; Wei Li; Sushmita Rane; Qigui Yu
Journal: J Virol Date: 2019-09-12 Impact factor: 5.103

4. Recombinant vaccinia virus-induced T-cell immunity: quantitation of the response to the virus vector and the foreign epitope.

Authors: Laurie E Harrington; Robbert van der Most Rv; J Lindsay Whitton; Rafi Ahmed
Journal: J Virol Date: 2002-04 Impact factor: 5.103

Review 5. Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens.

Authors: Magdalini Moutaftsi; David C Tscharke; Kerrie Vaughan; David M Koelle; Lawrence Stern; Mauricio Calvo-Calle; Francis Ennis; Masanori Terajima; Gerd Sutter; Shane Crotty; Ingo Drexler; Genoveffa Franchini; Jon W Yewdell; Steven R Head; Janice Blum; Bjoern Peters; Alex Sette
Journal: Future Microbiol Date: 2010-02 Impact factor: 3.165

Poxviruses as expression vectors.

1. Recombinant vaccinia viruses. Design, generation, and isolation.

2. Vaccinia virus-specific CD8(+) T-cell responses target a group of epitopes without a strong immunodominance hierarchy in humans.

3. Primary Human B Cells at Different Differentiation and Maturation Stages Exhibit Distinct Susceptibilities to Vaccinia Virus Binding and Infection.

4. Recombinant vaccinia virus-induced T-cell immunity: quantitation of the response to the virus vector and the foreign epitope.

Review 5. Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens.

Review 6. Phase III HIV vaccine trial in Thailand: a step toward a protective vaccine for HIV.

7. Comparison of monkeypox viruses pathogenesis in mice by in vivo imaging.

Review 8. Human immunodeficiency virus vaccine trials.

9. Purification of recombinant vaccinia virus-expressed monomeric HIV-1 gp120 to apparent homogeneity.

10. CD4+ T cells provide intermolecular help to generate robust antibody responses in vaccinia virus-vaccinated humans.