Literature DB >> 9353081

Differential immunogenicity of novel Mycobacterium tuberculosis antigens derived from live and dead bacilli.

R R Amara1, V Satchidanandam.   

Abstract

Mouse serum raised against killed antigen preparations of Mycobacterium tuberculosis failed to recognize most of the recombinant antigens of M. tuberculosis that were originally identified by reactivity to tuberculosis (TB) patient sera. Similar results were obtained with serum from guinea pigs immunized with live and killed mycobacteria. Antibodies raised against seven random TB patient serum-reactive antigens detected each of these antigens in the sonicate preparation. The nucleotide sequences of the genes for these seven antigens revealed that all represented hitherto unreported genes of M. tuberculosis. Our results suggest differential presentation to the host immune system of the same antigens derived from live and killed mycobacteria.

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Year:  1997        PMID： 9353081      PMCID： PMC175702          DOI： 10.1128/iai.65.11.4880-4882.1997

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  9 in total

1.  The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis.

Authors:  I M Orme
Journal:  J Immunol       Date:  1987-01-01       Impact factor: 5.422

2.  Responsiveness to live M. tuberculosis, and common antigens, of sonicate-stimulated T cell lines from normal donors.

Authors:  G A Rook; J Steele; S Barnass; J Mace; J L Stanford
Journal:  Clin Exp Immunol       Date:  1986-01       Impact factor: 4.330

Review 3.  The relationship of delayed hypersensitivity to acquired cellular resistance.

Authors:  G B Mackaness
Journal:  Br Med Bull       Date:  1967-01       Impact factor: 4.291

4.  Characteristics and specificity of acquired immunologic memory to Mycobacterium tuberculosis infection.

Authors:  I M Orme
Journal:  J Immunol       Date:  1988-05-15       Impact factor: 5.422

5.  Adoptive protection of the Mycobacterium tuberculosis-infected lung. Dissociation between cells that passively transfer protective immunity and those that transfer delayed-type hypersensitivity to tuberculin.

Authors:  I M Orme; F M Collins
Journal:  Cell Immunol       Date:  1984-03       Impact factor: 4.868

6.  Analysis of a genomic DNA expression library of Mycobacterium tuberculosis using tuberculosis patient sera: evidence for modulation of host immune response.

Authors:  R R Amara; V Satchidanandam
Journal:  Infect Immun       Date:  1996-09       Impact factor: 3.441

7.  Bacterial infection as assessed by in vivo gene expression.

Authors:  D M Heithoff; C P Conner; P C Hanna; S M Julio; U Hentschel; M J Mahan
Journal:  Proc Natl Acad Sci U S A       Date:  1997-02-04       Impact factor: 11.205

8.  Induction of nonspecific acquired resistance and delayed-type hypersensitivity, but not specific acquired resistance in mice inoculated with killed mycobacterial vaccines.

Authors:  I M Orme
Journal:  Infect Immun       Date:  1988-12       Impact factor: 3.441

9.  Identification of a Mycobacterium bovis BCG 45/47-kilodalton antigen complex, an immunodominant target for antibody response after immunization with living bacteria.

Authors:  F Romain; A Laqueyrerie; P Militzer; P Pescher; P Chavarot; M Lagranderie; G Auregan; M Gheorghiu; G Marchal
Journal:  Infect Immun       Date:  1993-02       Impact factor: 3.441
  9 in total
  2 in total

1.  Crystal structure of calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium-binding site.

Authors:  Arulandu Arockiasamy; Anup Aggarwal; Christos G Savva; Andreas Holzenburg; James C Sacchettini
Journal:  Protein Sci       Date:  2011-03-30       Impact factor: 6.725

2.  The glycosylated Rv1860 protein of Mycobacterium tuberculosis inhibits dendritic cell mediated TH1 and TH17 polarization of T cells and abrogates protective immunity conferred by BCG.

Authors:  Vijaya Satchidanandam; Naveen Kumar; Rajiv S Jumani; Vijay Challu; Shobha Elangovan; Naseem A Khan
Journal:  PLoS Pathog       Date:  2014-06-12       Impact factor: 6.823
  2 in total

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