Literature DB >> 9352531

In vivo radiotracers for vesicular neurotransmitter transporters.

M R Kilbourn1.   

Abstract

The vesicular monoamine transporter is a specific presynaptic protein involved in the transport of monoamines from the cytosol to storage vesicles of monoaminergic nerve terminals. Recently, radioligands for this transporter have been developed and utilized for in vivo positron emission tomographic (PET) imaging of monoaminergic nerve terminals in the human brain. In this review, the characteristics of vesicular transport and storage that provided the impetus for development of these radioligands are presented and discussed.

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Year:  1997        PMID： 9352531     DOI： 10.1016/s0969-8051(97)00101-7

Source DB:  PubMed          Journal:  Nucl Med Biol        ISSN： 0969-8051            Impact factor:   2.408


  9 in total

1.  New fluorescent substrate enables quantitative and high-throughput examination of vesicular monoamine transporter 2 (VMAT2).

Authors:  Gang Hu; Adam Henke; Richard J Karpowicz; Mark S Sonders; Frances Farrimond; Robert Edwards; David Sulzer; Dalibor Sames
Journal:  ACS Chem Biol       Date:  2013-07-16       Impact factor: 5.100

2.  Characterization of optically resolved 9-fluoropropyl-dihydrotetrabenazine as a potential PET imaging agent targeting vesicular monoamine transporters.

Authors:  Mei-Ping Kung; Catherine Hou; Rajesh Goswami; Datta E Ponde; Michael R Kilbourn; Hank F Kung
Journal:  Nucl Med Biol       Date:  2007-04       Impact factor: 2.408

3.  Pharmacokinetics of [(18)F]fluoroalkyl derivatives of dihydrotetrabenazine in rat and monkey brain.

Authors:  Michael R Kilbourn; Brian Hockley; Lihsueh Lee; Catherine Hou; Rajesh Goswami; Datta E Ponde; Mei-Ping Kung; Hank F Kung
Journal:  Nucl Med Biol       Date:  2007-04       Impact factor: 2.408

Review 4.  The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids.

Authors:  Bruno Gasnier
Journal:  Pflugers Arch       Date:  2003-05-16       Impact factor: 3.657

5.  Synthesis of (±)-Tetrabenazine by Visible Light Photoredox Catalysis.

Authors:  Lindsey R Orgren; Emily E Maverick; Christopher C Marvin
Journal:  J Org Chem       Date:  2015-11-13       Impact factor: 4.354

6.  In vivo imaging of vesicular monoamine transporter 2 in pancreas using an (18)F epoxide derivative of tetrabenazine.

Authors:  Hank F Kung; Brian P Lieberman; Zhi-Ping Zhuang; Shunichi Oya; Mei-Ping Kung; Seok Rye Choi; Karl Poessl; Eric Blankemeyer; Catherine Hou; Daniel Skovronsky; Michael Kilbourn
Journal:  Nucl Med Biol       Date:  2008-11       Impact factor: 2.408

7.  Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model.

Authors:  Fabiola Souza; Norman Simpson; Anthony Raffo; Chitra Saxena; Antonella Maffei; Mark Hardy; Michael Kilbourn; Robin Goland; Rudolph Leibel; J John Mann; Ronald Van Heertum; Paul E Harris
Journal:  J Clin Invest       Date:  2006-05-18       Impact factor: 14.808

Review 8.  PET probes beyond (18)F-FDG.

Authors:  Lei Jiang; Yingfeng Tu; Hongcheng Shi; Zhen Cheng
Journal:  J Biomed Res       Date:  2014-04-15

9.  Diagnostic value of striatal 18F-FP-DTBZ PET in Parkinson's disease.

Authors:  Xiu-Lin Liu; Shu-Ying Liu; Olivier Barret; Gilles D Tamagnan; Hong-Wen Qiao; Tian-Bin Song; Jie Lu; Piu Chan
Journal:  Front Aging Neurosci       Date:  2022-07-22       Impact factor: 5.702
  9 in total

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