| Literature DB >> 9351022 |
I Mottet1, R Demeure, J Rataud, M Lucas, F Wahl, V Warscotte, J P Thiran, J F Goudemant, B Maldague, J M Maloteaux, J M Stutzmann.
Abstract
The aim of this study was to investigate the effects of riluzole on the lesion induced by a permanent middle cerebral artery occlusion (MCAO) in rats. Riluzole at 4 or 8 mg/kg i.v. significantly reduced the cortical ischemic brain damage. With the most effective dose of 8 mg/kg, the time evolution of the lesion was assessed by T2-weighted magnetic resonance imaging (MRI) repeated on the same animals after MCAO. MRI obtained at 24, 48, and 72 hours after MCAO showed a progressive increase of the ischemic lesion, except in the cortex of the riluzole-treated rats (8 mg/kg i.v.). Furthermore, there was no difference between lesion volumes as measured by MRI or by histology. This study indicates that MRI may be a valuable method to quantify in vivo the neuroprotective profile of a drug.Entities:
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Year: 1997 PMID： 9351022 DOI： 10.1007/bf02594581
Source DB: PubMed Journal: MAGMA ISSN： 0968-5243 Impact factor: 2.310