| Literature DB >> 9349681 |
E M Wicklein1, G Pfeiffer, N Yuki, C Hartard, K Kunze.
Abstract
Sensitization with GD1b has been shown to cause sensory neuropathy in rabbit. A patient with chronic sensory-dominant polyneuropathy who had IgM antibody specifically to GD1b has been reported previously. This report describes the first patient with acute demyelinating polyneuropathy with prominent sensory symptoms who had a high titer of serum IgG anti-GD1b antibody. The serum reacted with neither GM1 nor with other b-series gangliosides (GD2, GD3, GT1b and GQ1b). Improvement in symptoms was coincident with decrease in IgG anti-GD1b antibody titer after plasmapheresis. This case supports the experimental results in rabbit suggesting that anti-GD1b antibody functions in the development of sensory ataxia.Entities:
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Year: 1997 PMID： 9349681 DOI： 10.1016/s0022-510x(97)00136-6
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181