| Literature DB >> 9348038 |
Abstract
The somatic genomic methylation pattern which plays a role in the suppression of basal gene activity is established anew in each generation through developmentally regulated de novo and demethylation steps. Demethylation appears to be carried out by a nucleotide exchange reaction which may involve RNA molecules, and is directed to specific loci in the genome through interactions between cis acting elements and trans acting factors.Mesh：
Year: 1997 PMID： 9348038 DOI： 10.1046/j.1365-2443.1997.1390337.x
Source DB: PubMed Journal: Genes Cells ISSN： 1356-9597 Impact factor: 1.891