Literature DB >> 9345404

Treatment of relapsing-remitting multiple sclerosis with natural interferon beta: a multicenter, randomized clinical trial.

O Fernández1, A Antiquëdad, T Arbizu, A Capdevíla, P de Castro, J C Correa de Sa, J A García-Merino, G Izquierdo, A Magalhaes, X Montalbán.   

Abstract

Preliminary results of a multicenter, randomized study on the effect of natural interferon beta (n-INFN-beta) in relapsing-remitting MS are reported. Sixty patients received either no treatment or n-IFN-beta (9 MIU three times a week, subcutaneously). After 6 months, the n-IFN-beta-treated group showed a 58% median reduction in the number of active lesions detected on monthly magnetic resonance imaging scans as well as a 38% reduction in the exacerbation rate as compared with the control group. Side-effects were mild and self-limiting. The study continues according to the protocol.

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Year:  1995        PMID: 9345404

Source DB:  PubMed          Journal:  Mult Scler        ISSN: 1352-4585            Impact factor:   6.312


  3 in total

1.  Microglial production of TNF-alpha is induced by activated T lymphocytes. Involvement of VLA-4 and inhibition by interferonbeta-1b.

Authors:  S Chabot; G Williams; V W Yong
Journal:  J Clin Invest       Date:  1997-08-01       Impact factor: 14.808

Review 2.  Interferons in relapsing-remitting multiple sclerosis: are there benefits from long-term use?

Authors:  Oscar Fernández
Journal:  CNS Drugs       Date:  2004       Impact factor: 5.749

Review 3.  Optimizing therapeutics in the management of patients with multiple sclerosis: a review of drug efficacy, dosing, and mechanisms of action.

Authors:  Kavitha Damal; Emily Stoker; John F Foley
Journal:  Biologics       Date:  2013-11-27
  3 in total

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