J Koo1. 1. UCSF Psoriasis and Skin Treatment Center, University of California, San Francisco 94143, USA.
Abstract
BACKGROUND: Calcipotriol/calcipotriene (Dovonex/Daivonex) ointment plus phototherapy has been used in the treatment of psoriasis. OBJECTIVE: We will attempt to clarify two issues: First, is there any benefit to combining the above treatment modalities? Second, is there any increased risk associated with the use of the combination? METHODS: A complete review of the literature revealed four studies dealing with the combination of calcipotriol with UVB phototherapy and three studies dealing with the combination of calcipotriol with PUVA phototherapy. RESULTS: These studies showed an advantage to the use of the combination compared with the use of either treatment alone. CONCLUSION: Topical calcipotriol enhances the effect of UVB and PUVA phototherapy.
BACKGROUND:Calcipotriol/calcipotriene (Dovonex/Daivonex) ointment plus phototherapy has been used in the treatment of psoriasis. OBJECTIVE: We will attempt to clarify two issues: First, is there any benefit to combining the above treatment modalities? Second, is there any increased risk associated with the use of the combination? METHODS: A complete review of the literature revealed four studies dealing with the combination of calcipotriol with UVB phototherapy and three studies dealing with the combination of calcipotriol with PUVA phototherapy. RESULTS: These studies showed an advantage to the use of the combination compared with the use of either treatment alone. CONCLUSION: Topical calcipotriol enhances the effect of UVB and PUVA phototherapy.