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Literature DB >> 9343259

Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells.

H Kaneko¹, L P Neoh, N Takeda, H Akimoto, T Hishikawa, H Hashimoto, S Hirose, S Karaki, M Takiguchi, H Nakauchi, Y Kaneko, N Yamamoto, I Sekigawa.

Abstract

We report here that human immunodeficiency virus type 2 (HIV-2) envelope glycoprotein (gp105), but not HIV-1 gp120, can bind to CD8 molecules as well as to CD4 molecules on human T cells. This phenomenon may lead to differences in the life cycles of HIV-1 and HIV-2, and it may be related to the differences in disease manifestations of HIV-1 and HIV-2 infection, including longer survival of HIV-2-infected patients.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1997 PMID： 9343259 PMCID： PMC192365

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

41 in total

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4 in total