Literature DB >> 9342772

Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity.

V Butterweck1, A Wall, U Liefländer-Wulf, H Winterhoff, A Nahrstedt.   

Abstract

A commercially available extract of the aerial parts of Hypericum perforatum, LI 160, showed pronounced activity in selected animal bioassays. These include the forced swimming test (FST) and the tail suspension test, used to determine antidepressant activity, and tests indicating activity on the central nervous system, such as body temperature and ketamine induced sleeping time. The counteracting effects of drugs known to interfere with the central dopaminergic system strongly suggested that dopamine mediated activity is important for the activity of the extract. Dose-response experiments of the total extract and of fractions rich in flavonoids and napthodianthrones produced inverted U-shaped dose response curves.

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Year:  1997        PMID： 9342772     DOI： 10.1055/s-2007-979531

Source DB:  PubMed          Journal:  Pharmacopsychiatry        ISSN： 0176-3679            Impact factor:   5.788


  14 in total

1.  Autoradiographic quantification of neurochemical markers of serotonin, dopamine and opioid systems in rat brain mesolimbic regions following chronic St John's wort treatment.

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2.  Safety and pharmacokinetics of naringenin: A randomized, controlled, single-ascending-dose clinical trial.

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Journal:  Diabetes Obes Metab       Date:  2019-09-30       Impact factor: 6.577

3.  St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.

Authors:  L B Moore; B Goodwin; S A Jones; G B Wisely; C J Serabjit-Singh; T M Willson; J L Collins; S A Kliewer
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-20       Impact factor: 11.205

4.  Effect of the herbal extract combination Panax quinquefolium and Ginkgo biloba on attention-deficit hyperactivity disorder: a pilot study.

Authors:  M R Lyon; J C Cline; J Totosy de Zepetnek; J J Shan; P Pang; C Benishin
Journal:  J Psychiatry Neurosci       Date:  2001-05       Impact factor: 6.186

5.  Hypericin prolongs action potential duration in hippocampal neurons by acting on K+ channels.

Authors:  Y Wang; X Shi; Z Qi
Journal:  Br J Pharmacol       Date:  2010-03-02       Impact factor: 8.739

Review 6.  Mechanism of action of St John's wort in depression : what is known?

Authors:  Veronika Butterweck
Journal:  CNS Drugs       Date:  2003       Impact factor: 5.749

7.  Hypericum perforatum L.: a medicinal plant with potential as a curative agent against obesity-associated complications.

Authors:  Hilal Büşra Tokgöz; Filiz Altan
Journal:  Mol Biol Rep       Date:  2020-10-22       Impact factor: 2.316

8.  Effect of Hypericum perforatum Extract in an Experimental Model of Binge Eating in Female Rats.

Authors:  Maria Vittoria Micioni Di Bonaventura; Giovanni Vitale; Maurizio Massi; Carlo Cifani
Journal:  J Obes       Date:  2012-09-10

Review 9.  St. John's wort: role of active compounds for its mechanism of action and efficacy.

Authors:  Veronika Butterweck; Mathias Schmidt
Journal:  Wien Med Wochenschr       Date:  2007

10.  Clinical effects of korean red ginseng on attention deficit hyperactivity disorder in children: an observational study.

Authors:  Suk Hwa Lee; Woo Sung Park; Myung Ho Lim
Journal:  J Ginseng Res       Date:  2011-06       Impact factor: 6.060
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