W Noske1, J Hensen, M Wiederholt. 1. Department of Ophthalmology, Benjamin Franklin University Hospital, Free University of Berlin, Germany.
Abstract
BACKGROUND: Experimental evidence suggests a role of endothelin-1 (ET) in the regulation of intraocular pressure (IOP). METHOD: Therefore, in patients undergoing cataract surgery, ET-like immunoreactivity (ETIR) was measured by radioimmunoassay in pooled samples of aqueous humor of eyes with primary open-angle glaucoma (POAG) and normotensive eyes with cataract only. RESULTS: ETIR was significantly (P < 0.05) higher in patients with cataract and POAG (20.5 +/- 1.8 pg/ml, n = 12; preoperative IOP 21.4 +/- 1.1 mmHg, n = 33) than in patients with cataract only (15.8 +/- 1.6 pg/ml, n = 15; preoperative IOP 16.0 +/- 0.6 mmHg, n = 77). CONCLUSION: This finding may indicate a role of ET in POAG or ocular antihypertensive treatment, and its relevance should be further investigated.
BACKGROUND: Experimental evidence suggests a role of endothelin-1 (ET) in the regulation of intraocular pressure (IOP). METHOD: Therefore, in patients undergoing cataract surgery, ET-like immunoreactivity (ETIR) was measured by radioimmunoassay in pooled samples of aqueous humor of eyes with primary open-angle glaucoma (POAG) and normotensive eyes with cataract only. RESULTS: ETIR was significantly (P < 0.05) higher in patients with cataract and POAG (20.5 +/- 1.8 pg/ml, n = 12; preoperative IOP 21.4 +/- 1.1 mmHg, n = 33) than in patients with cataract only (15.8 +/- 1.6 pg/ml, n = 15; preoperative IOP 16.0 +/- 0.6 mmHg, n = 77). CONCLUSION: This finding may indicate a role of ET in POAG or ocular antihypertensive treatment, and its relevance should be further investigated.
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