Literature DB >> 9342201

Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder.

L Oruc1, G R Verheyen, I Furac, M Jakovljević, S Ivezić, P Raeymaekers, C Van Broeckhoven.   

Abstract

We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5-HTR2c) and serotonin transporter (5-HTT) genes. No significant associations were found in the total patient sample. However, when the individuals were divided according to gender, trends for association with both polymorphisms (P = 0.051 for 5-HTR2c and P = 0.049 for 5-HTT) in female patients were observed. These results suggest that variations in these genes may be responsible for a minor increase in susceptibility for bipolar disorder in women.

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Year:  1997        PMID： 9342201

Source DB:  PubMed          Journal:  Am J Med Genet        ISSN： 0148-7299


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