Literature DB >> 934048

The effect of nitrosoguanidine upon DNA synthesis in vitro.

A Jiménez-Sánchez.   

Abstract

Both the polymerase and the exonuclease activities of DNA polymerase III are inactivated by treatment with nitrosoguanidine. The treatment of the DNA template with the mutagen does not affect the template in supporting DNA synthesis. No effect of nitrosoguanidine upon fidelity of replication in vitro was detected.

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Year:  1976        PMID： 934048     DOI： 10.1007/bf00269582

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  23 in total

1.  DNA polymerase 3 and the replication of F and ColVBtrp in Escherichia coli K-12.

Authors:  R Thompson; P Broda
Journal:  Mol Gen Genet       Date:  1973-12-31

2.  Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4.

Authors:  N Muzyczka; R L Poland; M J Bessman
Journal:  J Biol Chem       Date:  1972-11-25       Impact factor: 5.157

3.  Deoxyribonucleic acid synthesis in cell-free extracts. IV. Purification and catalytic properties of deoxyribonucleic acid polymerase III.

Authors:  T Kornberg; M L Gefter
Journal:  J Biol Chem       Date:  1972-09-10       Impact factor: 5.157

4.  A new form of DNA polymerase 3 and a copolymerase replicate a long, single-stranded primer-template.

Authors:  W Wickner; R Schekman; K Geider; A Kornberg
Journal:  Proc Natl Acad Sci U S A       Date:  1973-06       Impact factor: 11.205

5.  Erroneous base-pairing induced by a chemical carcinogen during DNA synthesis.

Authors:  M A Sirover; L A Loeb
Journal:  Nature       Date:  1974-11-29       Impact factor: 49.962

6.  DNA polymerase 3 star requires ATP to start synthesis on a primed DNA.

Authors:  W Wickner; A Kornberg
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

7.  Mutation and DNA replication in Escherichia coli treated with low concentrations of N-methyl-N'-nitro-N-nitrosoguanidine.

Authors:  A Jiménez-Sánchez; E Cerdá-Olmedo
Journal:  Mutat Res       Date:  1975-06       Impact factor: 2.433

Review 8.  Mechanism of enzyme action.

Authors:  A S Mildvan
Journal:  Annu Rev Biochem       Date:  1974       Impact factor: 23.643

9.  Involvement of two protein factors and ATP in in vitro DNA synthesis catalyzed by DNA polymerase 3 of Escherichia coli.

Authors:  J Hurwitz; S Wickner
Journal:  Proc Natl Acad Sci U S A       Date:  1974-01       Impact factor: 11.205

10.  Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N'-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation.

Authors:  P D Lawley; C J Thatcher
Journal:  Biochem J       Date:  1970-02       Impact factor: 3.857
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  4 in total

1.  Antimutagenic effects of caffeine during nitrosoguanidine-induced mutagenesis of Salmonella typhimurium cells and phages.

Authors:  P Háva; A Hejlová; L Sosková
Journal:  Folia Microbiol (Praha)       Date:  1978       Impact factor: 2.099

2.  The role of umuC gene product in mutagenesis by simple alkylating agents.

Authors:  P F Schendel; M Defais
Journal:  Mol Gen Genet       Date:  1980

3.  Single-strand binding protein enhances fidelity of DNA synthesis in vitro.

Authors:  T A Kunkel; R R Meyer; L A Loeb
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

4.  An Escherichia coli mutant refractory to nitrosoguanidine mutagenesis.

Authors:  R Ruiz-Vázquez; E Cerdá-Olmedo
Journal:  Mol Gen Genet       Date:  1980
  4 in total

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