Literature DB >> 9339355

A 1.2-megabase BAC/PAC contig spanning the 14q13 breakpoint of t(2; 14) in a mirror-image polydactyly patient.

N Matsumoto1, E Soeda, H Ohashi, M Fujimoto, R Kato, T Tsujita, H Tomita, S Kondo, Y Fukushima, N Niikawa.   

Abstract

We previously assigned a 14q13 breakpoint of t(2; 14) in a patient with mirror-image polydactyly to a segment between two loci, AFM200ZH4 and D14S306, within a genetic distance of 0.6 cM. In the present study, we constructed a 1.2-Mb high-resolution physical map with a contig composed of 16 bacterial artificial chromosomes (BACs) and 6 P1-derived artificial chromosomes (PACs) at a region around the breakpoint, extending from D14S75 to D14S728 loci. Thirty-four novel sequence-tagged sites (STSs) were also characterized at this region. Of nine ESTs that had been mapped between D14S75 and D14S288, T99065 was confirmed to be in two BAC clones, B102 and B319. This BAC/PAC contig with STSs is useful for further genomic sequencing, for construction of a transcription map, and for the isolation of the putative gene for mirror-image polydactyly.

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Year:  1997        PMID： 9339355     DOI： 10.1006/geno.1997.4897

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  7 in total

1.  Olfactory receptor-gene clusters, genomic-inversion polymorphisms, and common chromosome rearrangements.

Authors:  S Giglio; K W Broman; N Matsumoto; V Calvari; G Gimelli; T Neumann; H Ohashi; L Voullaire; D Larizza; R Giorda; J L Weber; D H Ledbetter; O Zuffardi
Journal:  Am J Hum Genet       Date:  2001-02-26       Impact factor: 11.025

2.  Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen.

Authors:  T Ono; T Kurashige; N Harada; Y Noguchi; T Saika; N Niikawa; M Aoe; S Nakamura; T Higashi; A Hiraki; H Wada; H Kumon; L J Old; E Nakayama
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-13       Impact factor: 11.205

3.  Characterization of physical gap sizes at human telomeres.

Authors:  C M Lese; J A Fantes; H C Riethman; D H Ledbetter
Journal:  Genome Res       Date:  1999-09       Impact factor: 9.043

4.  Paroxysmal kinesigenic choreoathetosis locus maps to chromosome 16p11.2-q12.1.

Authors:  H a Tomita; S Nagamitsu; K Wakui; Y Fukushima; K Yamada; M Sadamatsu; A Masui; T Konishi; T Matsuishi; M Aihara; K Shimizu; K Hashimoto; M Mineta; M Matsushima; T Tsujita; M Saito; H Tanaka; S Tsuji; T Takagi; Y Nakamura; S Nanko; N Kato; Y Nakane; N Niikawa
Journal:  Am J Hum Genet       Date:  1999-12       Impact factor: 11.025

Review 5.  Current status of human chromosome 14.

Authors:  D Kamnasaran; D W Cox
Journal:  J Med Genet       Date:  2002-02       Impact factor: 6.318

6.  Isolation of BAC clones spanning the Xq22.3 translocation breakpoint in a lissencephaly patient with a de novo X;2 translocation.

Authors:  N Matsumoto; D T Pilz; J A Fantes; K Kittikamron; D H Ledbetter
Journal:  J Med Genet       Date:  1998-10       Impact factor: 6.318

7.  An optimized set of human telomere clones for studying telomere integrity and architecture.

Authors:  S J Knight; C M Lese; K S Precht; J Kuc; Y Ning; S Lucas; R Regan; M Brenan; A Nicod; N M Lawrie; D L Cardy; H Nguyen; T J Hudson; H C Riethman; D H Ledbetter; J Flint
Journal:  Am J Hum Genet       Date:  2000-06-22       Impact factor: 11.043
  7 in total

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