H Y Lee1. 1. Department of Obstetrics & Gynaecology, Kuantan General Hospital, Kuantan Pahang, Malaysia.
Abstract
BACKGROUND:Dinoprostone, is presently used in our standard protocol for cervical ripening and labour induction. In search for a cheaper alternative, misoprostol has been found to be a good substitute. In view of the potential saving it might offer, we set out to test its efficacy against the standard dinoprostone. METHODS: A randomised double-blind study involving 50 pregnant women with prolonged pregnancy, treated at a government hospital in Malaysia, was carried out. Two hundred micrograms of intravaginal misoprostol were compared with 3 mg of dinoprostone in each treatment arm. RESULTS: In the misoprostol group, labour was successfully established in 92% of cases compared to 64% in the dinoprostone group (p = 0.04). The induction-delivery interval was shorter with more women delivering within 12 hours (72% vs 28%, p = 0.047). Maternal and neonatal complications, mode of delivery, the need for oxytocin and pethidine were quite similar statistically. Polysystole was more frequent (28% vs 12%, p = 0.28) in the misoprostol group but it was not associated with fetal distress. CONCLUSION: The study showed that misoprostol was a more effective drug in labour induction.
RCT Entities:
BACKGROUND:Dinoprostone, is presently used in our standard protocol for cervical ripening and labour induction. In search for a cheaper alternative, misoprostol has been found to be a good substitute. In view of the potential saving it might offer, we set out to test its efficacy against the standard dinoprostone. METHODS: A randomised double-blind study involving 50 pregnant women with prolonged pregnancy, treated at a government hospital in Malaysia, was carried out. Two hundred micrograms of intravaginal misoprostol were compared with 3 mg of dinoprostone in each treatment arm. RESULTS: In the misoprostol group, labour was successfully established in 92% of cases compared to 64% in the dinoprostone group (p = 0.04). The induction-delivery interval was shorter with more women delivering within 12 hours (72% vs 28%, p = 0.047). Maternal and neonatal complications, mode of delivery, the need for oxytocin and pethidine were quite similar statistically. Polysystole was more frequent (28% vs 12%, p = 0.28) in the misoprostol group but it was not associated with fetal distress. CONCLUSION: The study showed that misoprostol was a more effective drug in labour induction.
Entities:
Keywords:
Asia; Biology; Cervical Effects; Cervix; Clinical Research; Clinical Trials; Delivery; Demographic Factors; Developing Countries; Endocrine System; Genitalia; Genitalia, Female; Malaysia; Misoprostol--administraction and dosage; Physiology; Population; Population Characteristics; Pregnancy; Pregnancy Outcomes; Pregnancy, Prolonged; Pregnant Women; Prostaglandins; Prostaglandins, Synthetic--administraction and dosage; Reproduction; Research Methodology; Research Report; Southeastern Asia; Urogenital System; Uterus