| Literature DB >> 9338779 |
S D Yan1, J Fu, C Soto, X Chen, H Zhu, F Al-Mohanna, K Collison, A Zhu, E Stern, T Saido, M Tohyama, S Ogawa, A Roher, D Stern.
Abstract
Amyloid-beta is a neurotoxic peptide which is implicated in the pathogenesis of Alzheimer's disease. It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed in normal tissues, but is overexpressed in neurons affected in Alzheimer's disease. ERAB immunoprecipitates with amyloid-beta, and when cell cultures are exposed to amyloid-beta, ERAB inside the cell is rapidly redistributed to the plasma membrane. The toxic effect of amyloid-beta on these cells is prevented by blocking ERAB and is enhanced by overexpression of ERAB. By interacting with intracellular amyloid-beta, ERAB may therefore contribute to the neuronal dysfunction associated with Alzheimer's disease.Entities:
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Year: 1997 PMID： 9338779 DOI： 10.1038/39522
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962