Literature DB >> 9334770

Cochlear nucleus cell size changes in the dalmatian: model of congenital deafness.

J K Niparko1, P A Finger.   

Abstract

We assessed cellular changes in one population of neurons of the cochlear nucleus associated with a form of genetic deafness in deaf dalmatians. Spheric cells from deaf dalmatians and age-matched control (hearing) dogs were analyzed morphometrically. The somatic silhouette of these cells was reduced by 22.1% to 38.1%. The effect on cell size was greater with increased duration of deafness. Because the deaf dalmatian exhibits progressive degeneration of the auditory periphery, shrinkage of spheric cells may reflect the initial influence of attenuated activity of auditory nerve fibers, and sensorineural degeneration with longer periods of deafness.

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Mesh：

Year:  1997        PMID： 9334770     DOI： 10.1016/s0194-5998(97)70179-7

Source DB:  PubMed          Journal:  Otolaryngol Head Neck Surg        ISSN： 0194-5998            Impact factor:   3.497


  7 in total

1.  Deafness associated changes in expression of two-pore domain potassium channels in the rat cochlear nucleus.

Authors:  Avril Genene Holt; Mikiya Asako; R Keith Duncan; Catherine A Lomax; Jose M Juiz; Richard A Altschuler
Journal:  Hear Res       Date:  2006-05-02       Impact factor: 3.208

2.  Effects of age at onset of deafness and electrical stimulation on the developing cochlear nucleus in cats.

Authors:  Olga Stakhovskaya; Gary T Hradek; Russell L Snyder; Patricia A Leake
Journal:  Hear Res       Date:  2008-05-25       Impact factor: 3.208

3.  Brain-derived neurotrophic factor promotes cochlear spiral ganglion cell survival and function in deafened, developing cats.

Authors:  Patricia A Leake; Gary T Hradek; Alexander M Hetherington; Olga Stakhovskaya
Journal:  J Comp Neurol       Date:  2011-06-01       Impact factor: 3.215

4.  Vesicular glutamate transporters: spatio-temporal plasticity following hearing loss.

Authors:  B Fyk-Kolodziej; T Shimano; T-W Gong; A G Holt
Journal:  Neuroscience       Date:  2011-01-03       Impact factor: 3.590

5.  Deafness associated changes in two-pore domain potassium channels in the rat inferior colliculus.

Authors:  Y L Cui; A G Holt; C A Lomax; R A Altschuler
Journal:  Neuroscience       Date:  2007-07-17       Impact factor: 3.590

6.  Brain Morphological Modifications in Congenital and Acquired Auditory Deprivation: A Systematic Review and Coordinate-Based Meta-Analysis.

Authors:  Anaïs Grégoire; Naïma Deggouj; Laurence Dricot; Monique Decat; Ron Kupers
Journal:  Front Neurosci       Date:  2022-03-28       Impact factor: 4.677

Review 7.  Functional and structural changes throughout the auditory system following congenital and early-onset deafness: implications for hearing restoration.

Authors:  Blake E Butler; Stephen G Lomber
Journal:  Front Syst Neurosci       Date:  2013-11-26
  7 in total

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