Literature DB >> 9334743

Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.

A M Lawrie, M E Noble, P Tunnah, N R Brown, L N Johnson, J A Endicott.   

Abstract

Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 staurosporine complex explains the tight binding of this inhibitor, and suggests features to be exploited in the design of specific inhibitors of CDKs.

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Year:  1997        PMID： 9334743     DOI： 10.1038/nsb1097-796

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN： 1072-8368


  38 in total

1.  A comparison of the pharmacophore identification programs: Catalyst, DISCO and GASP.

Authors:  Yogendra Patel; Valerie J Gillet; Gianpaolo Bravi; Andrew R Leach
Journal:  J Comput Aided Mol Des       Date:  2002 Aug-Sep       Impact factor: 3.686

2.  Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase.

Authors:  Carl Mieczkowski; Anthony T Iavarone; Tom Alber
Journal:  EMBO J       Date:  2008-11-13       Impact factor: 11.598

3.  Transferable scoring function based on semiempirical quantum mechanical PM6-DH2 method: CDK2 with 15 structurally diverse inhibitors.

Authors:  Petr Dobeš; Jindřich Fanfrlík; Jan Rezáč; Michal Otyepka; Pavel Hobza
Journal:  J Comput Aided Mol Des       Date:  2011-02-01       Impact factor: 3.686

4.  Identification of new potential Mycobacterium tuberculosis shikimate kinase inhibitors through molecular docking simulations.

Authors:  Carolina Pasa Vianna; Walter F de Azevedo
Journal:  J Mol Model       Date:  2011-05-19       Impact factor: 1.810

5.  Discovery of thienoquinolone derivatives as selective and ATP non-competitive CDK5/p25 inhibitors by structure-based virtual screening.

Authors:  Arindam Chatterjee; Stephen J Cutler; Robert J Doerksen; Ikhlas A Khan; John S Williamson
Journal:  Bioorg Med Chem       Date:  2014-09-28       Impact factor: 3.641

6.  Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment.

Authors:  Ralf Jauch; Min-Kyu Cho; Stefan Jäkel; Catharina Netter; Kay Schreiter; Babette Aicher; Markus Zweckstetter; Herbert Jäckle; Markus C Wahl
Journal:  EMBO J       Date:  2006-08-17       Impact factor: 11.598

Review 7.  Selectivity and potency of cyclin-dependent kinase inhibitors.

Authors:  Jayalakshmi Sridhar; Nagaraju Akula; Nagarajan Pattabiraman
Journal:  AAPS J       Date:  2006-03-24       Impact factor: 4.009

8.  Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a.

Authors:  Nikolaus Schiering; Stefan Knapp; Marina Marconi; Maria M Flocco; Jean Cui; Rita Perego; Luisa Rusconi; Cinzia Cristiani
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-14       Impact factor: 11.205

9.  Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.

Authors:  H Mehenni; C Gehrig; J Nezu; A Oku; M Shimane; C Rossier; N Guex; J L Blouin; H S Scott; S E Antonarakis
Journal:  Am J Hum Genet       Date:  1998-12       Impact factor: 11.025

10.  The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling.

Authors:  Mohammad A Khanfar; Bilal Abu Asal; Mudit Mudit; Amal Kaddoumi; Khalid A El Sayed
Journal:  Bioorg Med Chem       Date:  2009-06-27       Impact factor: 3.641
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