Literature DB >> 9334741

Structure of the receptor binding fragment HC of tetanus neurotoxin.

T C Umland, L M Wingert, S Swaminathan, W F Furey, J J Schmidt, M Sax.   

Abstract

The 2.7 A structure of the tetanus neurotoxin receptor binding fragment Hc reveals a jelly-roll domain and a beta-trefoil domain. Hc retains the unique transport properties of the holotoxin and is capable of eliciting a protective immunological response against the full length holotoxin.

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Year:  1997        PMID： 9334741     DOI： 10.1038/nsb1097-788

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN： 1072-8368


  28 in total

1.  C-terminal half of tetanus toxin fragment C is sufficient for neuronal binding and interaction with a putative protein receptor.

Authors:  J Herreros; G Lalli; G Schiavo
Journal:  Biochem J       Date:  2000-04-01       Impact factor: 3.857

2.  High-affinity, protective antibodies to the binding domain of botulinum neurotoxin type A.

Authors:  D D Pless; E R Torres; E K Reinke; S Bavari
Journal:  Infect Immun       Date:  2001-01       Impact factor: 3.441

Review 3.  Tetanus.

Authors:  J J Farrar; L M Yen; T Cook; N Fairweather; N Binh; J Parry; C M Parry
Journal:  J Neurol Neurosurg Psychiatry       Date:  2000-09       Impact factor: 10.154

4.  Re-engineering the target specificity of Clostridial neurotoxins - a route to novel therapeutics.

Authors:  K A Foster; E J Adams; L Durose; C J Cruttwell; E Marks; C C Shone; J A Chaddock; C L Cox; C Heaton; J M Sutton; J Wayne; F C G Alexander; D F Rogers
Journal:  Neurotox Res       Date:  2006-04       Impact factor: 3.911

5.  A conformational change of C fragment of tetanus neurotoxin reduces its ganglioside-binding activity but does not destroy its immunogenicity.

Authors:  Rui Yu; Shaoqiong Yi; Changming Yu; Ting Fang; Shuling Liu; Ting Yu; Xiaohong Song; Ling Fu; Lihua Hou; Wei Chen
Journal:  Clin Vaccine Immunol       Date:  2011-08-03

6.  The structure of the tetanus toxin reveals pH-mediated domain dynamics.

Authors:  Geoffrey Masuyer; Julian Conrad; Pål Stenmark
Journal:  EMBO Rep       Date:  2017-06-23       Impact factor: 8.807

7.  Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.

Authors:  Andreas Rummel; Timo Eichner; Tanja Weil; Tino Karnath; Aleksandrs Gutcaits; Stefan Mahrhold; Konrad Sandhoff; Richard L Proia; K Ravi Acharya; Hans Bigalke; Thomas Binz
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-21       Impact factor: 11.205

Review 8.  Unique ganglioside binding by botulinum neurotoxins C and D-SA.

Authors:  Abby R Kroken; Andrew P-A Karalewitz; Zhuji Fu; Michael R Baldwin; Jung-Ja P Kim; Joseph T Barbieri
Journal:  FEBS J       Date:  2011-05-31       Impact factor: 5.542

9.  Biophysical comparison of diphtheria and tetanus toxins with the formaldehyde-detoxified toxoids, the main components of diphtheria and tetanus vaccines.

Authors:  Husam Alsarraf; Emil Dedic; Morten J Bjerrum; Ole Østergaard; Max Per Kristensen; Jesper W Petersen; René Jørgensen
Journal:  Virulence       Date:  2017-05-16       Impact factor: 5.882

10.  Multimeric bivalent immunogens from recombinant tetanus toxin HC fragment, synthetic hexasaccharides, and a glycopeptide adjuvant.

Authors:  Aileen F G Bongat; Rina Saksena; Roberto Adamo; Yukari Fujimoto; Zenyu Shiokawa; Dwight C Peterson; Koichi Fukase; Willie F Vann; Pavol Kovác
Journal:  Glycoconj J       Date:  2009-09-16       Impact factor: 2.916
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