Literature DB >> 9334307

Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate.

O Larsson1, C J Barker, A Sjöholm, H Carlqvist, R H Michell, A Bertorello, T Nilsson, R E Honkanen, G W Mayr, J Zwiller, P O Berggren.   

Abstract

Inositol hexakisphosphate (InsP6), the dominant inositol phosphate in insulin-secreting pancreatic beta cells, inhibited the serine-threonine protein phosphatases type 1, type 2A, and type 3 in a concentration-dependent manner. The activity of voltage-gated L-type calcium channels is increased in cells treated with inhibitors of serine-threonine protein phosphatases. Thus, the increased calcium channel activity obtained in the presence of InsP6 might result from the inhibition of phosphatase activity. Glucose elicited a transient increase in InsP6 concentration, which indicates that this inositol polyphosphate may modulate calcium influx over the plasma membrane and serve as a signal in the pancreatic beta cell stimulus-secretion coupling.

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Year:  1997        PMID： 9334307     DOI： 10.1126/science.278.5337.471

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  36 in total

1.  Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo.

Authors:  H Chi; X Yang; P D Kingsley; R J O'Keefe; J E Puzas; R N Rosier; S B Shears; P R Reynolds
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

2.  Inositol hexakisphosphate promotes dynamin I- mediated endocytosis.

Authors:  Marianne Høy; Alexander M Efanov; Alejandro M Bertorello; Sergei V Zaitsev; Hervør L Olsen; Krister Bokvist; Barbara Leibiger; Ingo B Leibiger; Jean Zwiller; Per-Olof Berggren; Jesper Gromada
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-14       Impact factor: 11.205

Review 3.  Defining signal transduction by inositol phosphates.

Authors:  Stephen B Shears; Sindura B Ganapathi; Nikhil A Gokhale; Tobias M H Schenk; Huanchen Wang; Jeremy D Weaver; Angelika Zaremba; Yixing Zhou
Journal:  Subcell Biochem       Date:  2012

4.  Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron.

Authors:  Shao-Nian Yang; Yue Shi; Guang Yang; Yuxin Li; Lina Yu; Ok-Ho Shin; Taulant Bacaj; Thomas C Südhof; Jia Yu; Per-Olof Berggren
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-09       Impact factor: 11.205

Review 5.  Protein phosphatases in pancreatic islets.

Authors:  Henrik Ortsäter; Nina Grankvist; Richard E Honkanen; Åke Sjöholm
Journal:  J Endocrinol       Date:  2014-03-28       Impact factor: 4.286

6.  Short- and long-term effects of beta-cellulin and transforming growth factor-alpha on beta-cell function in cultured fetal rat pancreatic islets.

Authors:  A Sjöholm; H Kindmark
Journal:  Endocrine       Date:  1999-10       Impact factor: 3.633

Review 7.  Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate.

Authors:  Karsten Sauer; Michael P Cooke
Journal:  Nat Rev Immunol       Date:  2010-04       Impact factor: 53.106

Review 8.  Aspects of novel sites of regulation of the insulin stimulus-secretion coupling in normal and diabetic pancreatic islets.

Authors:  A Sjöholm
Journal:  Endocrine       Date:  1998-08       Impact factor: 3.633

9.  Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation.

Authors:  P P Ongusaha; P J Hughes; J Davey; R H Michell
Journal:  Biochem J       Date:  1998-11-01       Impact factor: 3.857

10.  Inositol hexakisphosphate mobilizes an endomembrane store of calcium in guard cells.

Authors:  Fouad Lemtiri-Chlieh; Enid A C MacRobbie; Alex A R Webb; Nick F Manison; Colin Brownlee; Jeremy N Skepper; Jian Chen; Glenn D Prestwich; Charles A Brearley
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-11       Impact factor: 11.205
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