Literature DB >> 9332997

Low dose dopamine in postpartum pre-eclamptic women with oliguria: a double-blind, placebo controlled, randomised trial.

G D Mantel1, J D Makin.   

Abstract

OBJECTIVE: To assess the effect of low dose dopamine on the urine output in postpartum pre-eclamptic or eclamptic women with oliguria.
DESIGN: A double blind, randomised controlled study.
SETTING: The high care area of the labour ward in a teaching hospital. SAMPLE: Forty postpartum pre-eclamptic women with oliguria, defined as < 30 mL/hour, who have not responded to a 300 mL crystalloid fluid challenge. INTERVENTION: Dopamine was infused at a rate of 1 to 5 microg/kg per minute, or sterile water was given as placebo in the same dilution. MAIN OUTCOME MEASURE: Urine output, blood pressure and pulse was measured for six hours before and for six hours after the intervention.
RESULTS: Women who received dopamine (344 mL over 6 hours) showed a clinically and statistically significant (P = 0.0014, Mann-Whitney U test) higher median urine output compared with those receiving placebo (135 mL over 6 hours) for the duration of therapy. The respective 95% confidence intervals were 212.3 to 712.7 mL compared with 73.8 to 244.7 mL. No differences in blood pressure or pulse were found between the two groups.
CONCLUSIONS: The use of low dose dopamine in a labour setting improved urine output in postpartum pre-eclamptic women with oliguria who had not responded to a single fluid challenge without a detrimental effect on the blood pressure or pulse.

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Year:  1997        PMID: 9332997     DOI: 10.1111/j.1471-0528.1997.tb10943.x

Source DB:  PubMed          Journal:  Br J Obstet Gynaecol        ISSN: 0306-5456


  2 in total

Review 1.  Low-dose dopamine for women with severe pre-eclampsia.

Authors:  D W Steyn; P Steyn
Journal:  Cochrane Database Syst Rev       Date:  2007-01-24

2.  Evaluation of a strict protocol approach in managing women with severe disease due to hypertension in pregnancy: a before and after study.

Authors:  Hennie Lombaard; Robert C Pattinson; Fèbè Backer; Peter Macdonald
Journal:  Reprod Health       Date:  2005-09-30       Impact factor: 3.223

  2 in total

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