Literature DB >> 9331405

Bacterial protein secretion--a target for new antibiotics?

C Stephens1, L Shapiro.   

Abstract

The heavy use of antibiotics over recent decades has resulted in widespread resistance of bacteria to many drugs. Overcoming resistance requires new approaches to antibiotic development, including the exploitation of new targets in the bacterial cell. Protein secretion is essential for bacterial cell growth and virulence, so it could be a suitable target for new therapeutic agents.

Mesh：

Substances：

Year:  1997        PMID： 9331405     DOI： 10.1016/s1074-5521(97)90217-9

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  6 in total

1.  Identification and analysis of bacterial protein secretion inhibitors utilizing a SecA-LacZ reporter fusion system.

Authors:  L E Alksne; P Burgio; W Hu; B Feld; M P Singh; M Tuckman; P J Petersen; P Labthavikul; M McGlynn; L Barbieri; L McDonald; P Bradford; R G Dushin; D Rothstein; S J Projan
Journal:  Antimicrob Agents Chemother       Date:  2000-06       Impact factor: 5.191

Review 2.  SecA inhibitors as potential antimicrobial agents: differential actions on SecA-only and SecA-SecYEG protein-conducting channels.

Authors:  Jinshan Jin; Ying-Hsin Hsieh; Arpana S Chaudhary; Jianmei Cui; John E Houghton; Sen-Fang Sui; Binghe Wang; Phang C Tai
Journal:  FEMS Microbiol Lett       Date:  2018-08-01       Impact factor: 2.742

3.  Identification of small-molecule inhibitors against SecA by structure-based virtual ligand screening.

Authors:  Evelien De Waelheyns; Kenneth Segers; Marios Frantzeskos Sardis; Jozef Anné; Gerry A F Nicolaes; Anastassios Economou
Journal:  J Antibiot (Tokyo)       Date:  2015-05-20       Impact factor: 2.649

Review 4.  Coupling of flagellar gene expression to flagellar assembly in Salmonella enterica serovar typhimurium and Escherichia coli.

Authors:  G S Chilcott; K T Hughes
Journal:  Microbiol Mol Biol Rev       Date:  2000-12       Impact factor: 11.056

5.  Optimization of a β-Lactam Scaffold for Antibacterial Activity via the Inhibition of Bacterial Type I Signal Peptidase.

Authors:  Chien-Hung Yeh; Shawn I Walsh; Arryn Craney; M Greg Tabor; Ana-Florina Voica; Ramkrishna Adhikary; Sydney E Morris; Floyd E Romesberg
Journal:  ACS Med Chem Lett       Date:  2018-03-15       Impact factor: 4.345

6.  Fluorescein analogues inhibit SecA ATPase: the first sub-micromolar inhibitor of bacterial protein translocation.

Authors:  Ying-Ju Huang; Hongyun Wang; Fen-Biao Gao; Minyong Li; Hsiuchin Yang; Binghe Wang; Phang C Tai
Journal:  ChemMedChem       Date:  2012-02-22       Impact factor: 3.466
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.